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Exam (elaborations)

COMSAE Drugs study guide (latest update)

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Warfarin- Mechanism Interferes w/ vitamin K dependent clotting factors (II, VII, IX, X, C, S) Warfarin- Pathway, effect on PT/INR Extrinsic factor, increased PT Warfarin- Clinical Use Chronic anticoagulation Warfarin- Pregnancy CI in pregnant women--crosses placenta ...

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  • August 3, 2024
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  • 2024/2025
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COMSAE Drugs
study guide
(latest update)
Warfarin- Mechanism - answer Interferes w/
vitamin K dependent clotting factors (II, VII, IX, X,
C, S)


Warfarin- Pathway, effect on PT/INR - answer
Extrinsic factor, increased PT


Warfarin- Clinical Use - answer Chronic
anticoagulation


Warfarin- Pregnancy - answer CI in pregnant
women--crosses placenta


Warfarin- AE - answer Bleeding, tissue necrosis

, Digoxin- MOA - answer Direct inhibition of Na/K
ATPase --> indirect inhibition of Na/Ca exchange
Increased Calcium concentration --> positive
ionotropy.
Stimulates vagus nerve --> decrease HR


Digoxin- Clinical use - answer Heart failure
(increase contractility)
atrial fibrillation (decrease conduction at AV node
and depression of SA node)


Digoxin- AE - answer Hyperkalemia, blurry yellow
vision, arrhythmias, AV block


Digoxin Toxicity- Treatment - answer Slowly
normalize K+, cardiac pacer, anti-digoxin Fab
fragments, Mg+


Beta Blockers- Mechanism - answer Decrease SA
and AV nodal activity by decreasing cAMP/Ca2+
Decrease slope of phase 4

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