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CRO 2024 Study Guide Exam Questions & Answers 100% CORRECT
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CRO 2024 Study Guide Exam Questions & Answers 100% CORRECT What cell is the pathologic hallmark of Hodgkin's lymphoma? - ANSWERSReed-Sternberg cells derived from monoclonal B Cells Where in the body do patients with Hodgkin's lymphoma most often present with lymphadenopathy? - ANSWERS80% pr...

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  • August 5, 2024
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  • 2024/2025
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  • cro 2024 study guide exam questions answers 100

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CRO 2024 Study Guide Exam Questions
& Answers 100% CORRECT

What cell is the pathologic hallmark of Hodgkin's lymphoma? - ANSWERSReed-Sternberg cells derived
from monoclonal B Cells



Where in the body do patients with Hodgkin's lymphoma most often present with lymphadenopathy? -
ANSWERS80% present with cervical lymphadenopathy



What percentage of patients with Hodgkin's lymphoma present with B symptoms? - ANSWERS33%
present with B symptoms overall



B symptoms - a group of symptoms that may be present in individuals with lymphoma. There may be a
variety of symptoms in lymphoma patients. The most common is the enlargement of lymph nodes. Apart
from this, a set of 3 symptoms are considered very important in identifying how the cancer is likely to
behave. These are:

o Fever (i.e., temperature >38°C [>100.4°F]) for 3 consecutive days

o Weight loss exceeding 10% of body weight in 6 months

o Drenching night sweats



Describe the following radiation techniques used to treat Hodgkin's lymphoma: - ANSWERS• Mantle:
(name lymph nodes included in field) - bilateral cervical, SCV, infraclavicular, mediastinal, hilar, & axilla



• Mini-mantle: (name structures included in field) - mantle without mediastinum, hila



• Modified mantle (name structures included in field) - mantle without axilla



• Inverted Y (name lymph nodes included in field) - paraaortic, bilateral pelvic and inguinofemoral,
+splenic

, • Total lymphoid irradiation (TLI) - both mantle and inverted Y-fields



What structures are blocked in a mantle field used to treat Hodgkin's lymphoma? - ANSWERSLarynx on
AP field. Humeral heads on AP and PA fields. PA cord block (if dose >40 Gy). Lung block at top of 4th rib
to cover infraclavicular LN. If pericardial or mediastinal extension, include entire heart up to 15 Gy, then
block apex of heart. After 30 Gy, block heart beyond 5 cm inferior to carina (unless residual disease).



What is the median age for Non-Hodgkin's lymphoma? - ANSWERSMedian age 60-65 years



What are the causative conditions leading to Non Hodgkin's lymphoma? - ANSWERS• Immunodeficiency
- congenital, acquired (HIV, organ transplant), autoimmune

• Environmental - chemicals (pesticides and solvents)

• Viral - EBV

• Bacterial - H. pylori (MALT)

• Radiation - weak association

• Chemo - alkylating agents



• MALT lymphoma - a group of symptoms that may be present in individuals with lymphoma. A form of
lymphoma involving the mucosa-associated lymphoid tissue (MALT).



What anatomic structures does MALT involve? - ANSWERSInvolves stomach, ocular adnexae
(appendages of the eyeball, which includes the eyelids, muscles and soft tissue), skin, thyroid, parotid
gland, lung, and breast



Describe the epidemiology for cutaneous lymphoma. (i.e. age, male: female ratio, ethnic group): -
ANSWERSAffects older adults (55-60 years), 2:1 male predominance, blacks > whites



What is the usual presentation for cutaneous lymphoma? - ANSWERSSkin lesions, but long natural
history. Median time from skin lesion to diagnosis is 5 years.



What is the (overall) radiation dose used to treat cutaneous lymphoma? - ANSWERSLow doses effective,
24 - 36 Gy

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