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BOC ASCP Recalls Exam Questions with Complete Solutions Graded A
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  In the anti-double-stranded DNA procedure, the antigen most commonly utilized is: - Answer: The Crithidia luciliae antigen is used. C. luciliae has giant mitochondrion that contain native DNA that is free from contaminating histone antigens. It is used in SLE diagnosis. C3b function - Ans...

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  • August 11, 2024
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  • 2024/2025
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BOC ASCP Recalls
Exam Questions
with Complete
Solutions Graded
A+
Denning [Date] [Course title]

, In the anti-double-stranded DNA procedure, the antigen most commonly utilized is: - Answer: The
Crithidia luciliae antigen is used. C. luciliae has giant mitochondrion that contain native DNA that is free
from contaminating histone antigens. It is used in SLE diagnosis.



C3b function - Answer: which lands on the target surface and becomes part of C5 convertase, is also a
powerful opsonin



Rheumatoid factor - Answer: anti-Ig*M* or G that binds to the Fc portion of an abnormal IgG. + in 75%
of RA patients but also possible in some chronic infections,SLE or syphillis.



Rheumatoid arthritis general - Answer: systemic inflammatory disease. produce IgG or M** antibodies
against IgG in the synovium. forming an immune complex that activated complement. The inflammatory
response proceeds and destroys the synovium. Immune complexes attract neutrophils and macrophages
to the joint that degranulate and cause tissue destruction.. Symptoms: joint pain, morning stiffness,
rheumatoid nodules, vasculitis



Rheumatoid arthritis labs - Answer: increased: eSedRate, CRP,



positive: RF, cryoglobulins, ANA(homogenous)



synovial fluid: cloudy, WBC 5-20,000/uL, increased protein, poor mucin clot development, decreased
complement



allotype antibodies - Answer: allo=different



the types of antibodies found within one species



multiple alleles exist for the constant regions of the antibody heavy and light chains



So if we take antibodies from one member of the species and inject it into another member of the same
species it will result in production of antibodies against allotypic determinants. this is observed during
blood transfusions or pregnancys

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