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PCB 3233 Immunology Exam 4 Questions and Answers 100% Verified

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Single Positive - has either CD4 or CD8 CD2 and CD5 - perform adhesion and signaling. They are present during double negative stage Thymocytes rearrange which 3 genes at the same time? - Beta, gamma, and delta pTalpha - surrogate alpha chain. signals cell to halt gamma, delta, Beta chains, gene ...

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  • August 12, 2024
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  • 2024/2025
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PCB 3233 Immunology Exam 4
Single Positive - has either CD4 or CD8



CD2 and CD5 - perform adhesion and signaling. They are present during double negative stage



Thymocytes rearrange which 3 genes at the same time? - Beta, gamma, and delta



pTalpha - surrogate alpha chain. signals cell to halt gamma, delta, Beta chains, gene
rearrangement and begin proliferation.



What do macrophages do in the thymus? - continually remove dead cells



What does TH1 cells do? - Activate macrophages



Thymal Stromal Cells - Keeps BCR genes closed and opens TCR genes



IgM activates? - complement



Notch-1 - The signal for survival. It drives the cell on the T-cell path — signals to open up T-cell
rearrangement.



Signaling rearrangement keeps T-cel on T-cell pathway



Where does Maturation and Positive Selection occur? - Cortex of the thymus



Can negative selection also take place in the Cortex? - Yes, negative selection can take place in the
cortex at the same time as positive selection

,Where does negative selection take place? - medulla of thymus



Where are mature thymocytes located? - Medulla



Where are immature thymocytes located? - Cortex



What special cells are in the Medulla - Dendritic cells, macrophages, and medullary epithelial cells



What special cells are in the cortex? - Cortical epithelial cells and macrophages



Where can you find AIRE? - in the medullary epithelial cells



AIRE - Autoimmune regulator



made by medullary epithelial cells



Creates a couple hundred peripheral peptides that can be used to test T-cells for negative selection



DiGeorge's syndrome - deletion in chromosome 22 in which thymus fails to develop and T-cells
are absent

Positive Selection - makes sure that your T-Cell recognizes one of your MHC.



If it does not, then apoptosis



Negative Selection - Makes sure it does not recognize your peptide:MHC too strongly



Does gamma: delta T-cells have to go through positive selection? - No

, What does turning off RAG 1&2 do to your gene rearrangement? - Preserve the current
rearrangement



Primary Lymphoid Tissue - bone marrow and thymus



Hassall's corpuscles - macrophages in both cortex and medulla remove the many thymocytes that
fail to mature properly



Involution of the Thymus - Progressively shrinks, fat gradually claiming areas once packed with
thymocytes



-reduces production of new T-cells



Double negative - No CD4 and CD8



Double Positive - CD4 and CD8 are present




How many rearrangements can successfully make a Beta chain? - up to 4 attempts



d:k light chain can have a minimum of how many rearrangements? - 4 minimum attempts



alpha chain allows many successive rearrangements with a minimum of - 2 attempts



What is the first checkpoint in T-cell maturation? - Pre-TCR



Checking beta chain is a productive rearrangement



What is the second checkpoint in T-cell maturation? - TCR

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