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PCB 3233 IMMUNOLOGY - EXAM 3 Questions and Answers 100% Verified
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Which disease state is caused by loss of approximately 80% of the RAG proteins enzymatic activity and misssense mutation? (hint: infant has a red rash on the face and shoulders) - Omenn Syndrome Major histocompatibility complex class I presents: - Intracellular antigens to CD8 T cells __________...

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  • August 12, 2024
  • 5
  • 2024/2025
  • Exam (elaborations)
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  • pcb 3233 immunology

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PCB 3233 IMMUNOLOGY - EXAM 3
Which disease state is caused by loss of approximately 80% of the RAG proteins enzymatic activity and
misssense mutation? (hint: infant has a red rash on the face and shoulders) - Omenn Syndrome



Major histocompatibility complex class I presents: - Intracellular antigens to CD8 T cells



__________ has an alpha chain and a beta chain in their structure while ________ only has an alpha
chain in its structure? - MHC II, MHC I



What process(es) are used after activation to make MHC I and II binding sites better? - None of
the above (Somatic recombination, somatic hypermutation, isotype switching



Burkitt's lymphoma is due to a translocation of the ________ gene next of one of the ________ genes. -
MYC, Ig



You would expect the IgA and IgB genes to be turned on (expressed) during which stage/s? - All
the above (the small pre B cell, mature B cell, immature B cell



T-cell receptor diversity is established - Before antigen stimulation



The types of human MHC I presenting molecules are: - HLA-A, HLA-B and HLA-C which present
peptide to CD8 T-cells



Receptor editing - A & B (is done on the light chain, can be utilized in an attempt to rescue a B-cell
that has a self-reactive receptor



Which one of the following is in the correct sequence? - Early Pro-B, Late Pro-B, Large Pre-B, Small
Pre-B, Immature B-cell

, When/where are N and P nucleotide additions added to the variable regions (binding site? -
During somatic recombination



Which chemokine/s call/s a B-cell into the follicle of a secondary lymphoid tissue? - CXCL 13



Which cell/s is/are lymphocyte/s? - None of the above (neutrophils, macrophages, dendritic cells



Which of the following is/are considered proto-oncogenes? - A & B (BCL2, MYC)



A mature B-cell has: - IgM, IgD and IgA and IgB on the surface

Which cell types can become a plasma cell? - All the above (a memory B-cell, an activated B-cell, a
centrocyte



The types of human MHC II presenting molecules are: - HLA-DP, HLA-DQ, HLA-DR which present
peptide to CD4 T-cells



True of false: CCL19 and CCL21 direct a B-cell out of the blood stream, across HEV's and into a secondary
lymphocyte toward the T-cell era. - True



The peptide-binding groove of an MHC class I molecule is composed of the following extracelllular
dendritic cells? - a1 : a2



A beta (B) chain of a TCR has: - 1 variable region and 1 constant region



The genetic diversity of the MHC molecules binding site is due to: - Genetic polymorphism



Follicular dendritic cells: - A & B (are present in germinal centers, are present in secondary
lymphoid



True or false: A T-cell uses somatic hypermutation to make its binding site better. - False

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