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PCB 3233 - Immunology Exam 3 Questions and Answers 100% Verified
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What process creates the variable region domain for both TCRs and BCRs? - Somatic Recombination What the different types IFN-1? - Alpha and Beta What are the differences and similarities between CD8 T Cells and NK cells? - The both have the same cytotoxic granules, NK cells are activated faster...

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  • August 12, 2024
  • 6
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • pcb 3233 immunology

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  • PCB 3233 - Immunology

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PCB 3233 - Immunology Exam 3
What process creates the variable region domain for both TCRs and BCRs? - Somatic
Recombination



What the different types IFN-1? - Alpha and Beta



What are the differences and similarities between CD8 T Cells and NK cells? - The both have the
same cytotoxic granules, NK cells are activated faster, because they come out of the bone marrow "ready
to go". CD8 T cells recognizes MHC Class 1 + peptide (antigen) on a pathogen, while NK cells recognize
normal MHC Class 1 molecules on the surface of our cells and activating ligands that infected cells put up
on their surface.



2 types of activating ligands - MIC - A and MIC - B, they bind to activating receptors on activating
NK cells



Type 2 interferon - Also know as IFN- gamma, activates macrophages



IL - 12 - Inflammatory cytokine that activates NK cells which then produces IFN - gamma which
then activate macrophages.



Which complement receptors can recognize C3b? - CR 1 - CR 4



Which Professional Antigen Presenting Cell (Professional - APC) is strong enough to activate a CD8 T cell
from a naive state? - Dendritic cells



C3 convertase of the Alternative Pathway - C3bBb



When will NK cells make interferon gamma? - When they are activated by IL-12 (inflammatory
cytokine)

, Explain the activation of macrophage feedback loop - NK cells become activated by IL- 12, they
produce interferon gamma, IFN- gamma activates macrophages, macrophages secrete IL-12 (+ other
cytokines)

Helper T cells associate with which class of MHC molecules? - MHC Class 2 (extracellular infection)



Interferon function - Viral fighting, they activate NK cells which then tell our infected cells to die
by apoptosis.



Describe the chains in a TCR? - V region followed by a C region followed by a membrane
anchoring domain



Where is the most variable region of the TCR? - V-alpha and V- beta



CDR - area of hypervariability condensed in loops in domain farthest from the T cell membrane



How many CDRs does each TCR chain have? - 3, CDR 1 - 3



How many binding sites do TCRs have? - 1 binding site for antigen



Function of T cells - to recognize antigen



What part in T cells handles the mediating effector functions? - the proteins produced by the T
cells



Alpha Chain Chromosome - Chromosome 14



Beta Chain Chromosome - Chromosome 7



What happens during T cell development? - Somatic DNA recombination, alpha chain = V+J, beta
= (D+J) + V

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