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MICR 3230 immunology Final Exam tips new update University of Guelph
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MICR 3230 immunology Final Examtips new update University of Guelph
,MICR 3230 immunology Final Exam tips new update University of Guelph
T & B cells use what to recognize an antigen?
Surface molecules
B cell receptors can recognize:
A whole antigen
T cell receptors can recognize:
Antigen fragments that are displayed on the surface of other cells
Antigen fragments are held within:
The binding groove of a cell surface protein called the MHC molecule
MHCs act as:
Cell surface vessel for holding & displaying fragments of antigen so T cells can engage with this
molecular complex via their TCRs
There are ______ for most MHC genes:
Many alleles
Specific MHC allele inheritance plays a role in determining an individual's susceptibility to disease
What are the 2 main types of MHC molecules?
MHC Class I
MHC Class II
MHC class I:
Classification of self
Present on all nucleated cells in the body (except RBCs)
Specialize in presenting antigen that originates from the cytosol
Ass. with T cytotoxic cell
MHC class II:
Present mostly on APCs (macrophages, B cells, DCs)
Specialize in presenting antigen from extracellular spaces that have been engulfed by APCs
,Ass. with T helper cell
Mice VERSUS humans:
H-2 complex VERSUS HLA complex
RR =
(frequency of allele+/allele- in diseased population) /
(frequency of allele+/allele- in general population)
RR = 1 means:
No effect
MHC class I -
Is present on:
All nucleated cells except for RBCs
MHC class I -
Has how many chains?
2 chains
Alpha + beta 2 microglobulin (alpha, alpha, & beta)
MHC class I -
Info about the chains:
Alpha chain coded on chromosome 6
Beta chain coded on chromosome 15
Beta 2 microglobulin acts as stabilizer
Alpha & alpha form cleft region that binds 8-10 AA long peptide fragment from an antigen
Beta sheet forms the floor of the cleft
2 alpha helices form the walls
MHC class I -
Alpha vs. beta chain encoding:
Only alpha chain encoded in the MHC, beta joins separately
, MHC class I -
Presents peptide to:
CD8+ T cells (T cytotoxic)
MHC class I -
Responsible for:
Graft rejection & clearance of ENDOGENOUS antigens (tumour, pathogen infected cells, virus infected
cells)
MHC class I -
What helps to anchor the peptide in the groove?
Some AAs
Other AAs interact with TCR
MHC class II -
Is present on:
APCs (B cells, macrophages, DCs)
MHC class II -
Responsible for:
Graft rejection & clearance of EXOGENOUS antigens
MHC class II -
Derived from:
Self or foreign exogenous extracellular processed antigens
MHC class II -
Presents antigen peptides to:
CD4+ cells (T helper)
MHC class II -
Peptide binding cleft formed by:
Pairing of the alpha 1 & beta 1 domains
Exhibit anchor AA residues that lock them into the groove & extend within the 13 core AAs
Extends other AA residues from groove to interact with TCR
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