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BBH 311 Exam 2 Review Questions and Correct Answ
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Face valid models they're going to measure what they're supposed to Inference models use behavioral or biological response to infer processes related to humans What are the scientific guidelines of animal research? 1. Quality of research must be dependent on care, health, well-being, ethical trea...

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  • August 26, 2024
  • 6
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • bbh 311 exam 2 review questions and correct answ
  • face valid models theyre going to measure what t
  • inference models use behavioral or biological res

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BBH 311 Exam 2 Review Questions and
Correct Answers
Face valid models ✅they're going to measure what they're supposed to

Inference models ✅use behavioral or biological response to infer processes related to
humans

What are the scientific guidelines of animal research? ✅1. Quality of research must be
dependent on care, health, well-being, ethical treatment of animals
2. Follow laws + regulations at state, federal, institutional, community levels
3. Scientists must be trained in guidelines

What does penn state office for research protections do? ✅- ensure extensive training
of personnel
- research application review

Professional, community, and governmental levels of review include what aspects?
✅1. Justification of research
2. Personnel
3. Care & housing
4. Acquisition of animals
5. Experimental procedures
6. Field research
7. Educational use of animals, consider other models if possible

What are the three r's regarding human research? ✅1. Replace (may use a non animal
alternative)
2. Reduce (the # of animals used/effected)
3. Refine (less pain + distress)

What kind of research animals do we use? ✅- mice/rats majority (have biological
similarities to humans)
- may include rabbits/farm animals
- fruit flies/worms for genetic research

Mechanistic models ✅high specialization

rigid departmentalization

clear chain of command

narrows spans of control

, centralization
high formalization

What are some potential alternatives for animal research? ✅- many times, there is not
one
- may use test tube (in vitro), human cells/tissues, computer models, non-invasive
imaging

Aim of alzoubi ? ✅examine the effect of ptx drug on ptsd induced memory impairment
in rat model

Hypothesis of alzoubi ✅1. Ptx would have protective effect on learning ability +
memory functions in a rat model with ptsd behaviors
2. Ptx would modulate biomarkers of oxidative stress, bdnf, histones

What effect does stress exposure have on oxidative stress? ✅increases it

How does oxidative stress effect us? ✅alters neuronal integrity

What does brain-derived neurotropic factor (bdnf) do? ✅supports neuronal health, impt
in plasticity, learning, memory, higher thinking

What are hippocampal histones used for? ✅plasticity, long term memory, neuronal
health

What were the independent variables in alzoubi study? ✅1. Drug (ptx or placebo)
2. Stress (sps or no stress)

What were the 4 groups used in alzoubi study? ✅1) control - no drug, no stress
2) sps - stress, no drug
3) ptx - no stress, drug
4) ptx + stress

What methods were used in regards to drugs in the alzoubi study? ✅control rats
received saline
Experimental rats received 100mg/kg of ptx, 6 days a week for 4 weeks

What methods were used in regards to stress in alzoubi study? ✅- sps and ptx/sps got
sps one week after ptx admin
- sps with saline injection

What memory test was used in alzoubi study? ✅radial arm water maze

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