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Nurs 5315: Adv Patho Exam 2 Set 2 fully solved & updated

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Hemostasis termination of bleeding Two arms of hemostasis Platelet plug formation Coagulation cascade Previous Play Next Rewind 10 seconds Move forward 10 seconds Unmute 0:00 / 0:15 Full screen Brainpower Read More Platelet Plug *Primary response to bleeding *a coll...

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  • September 6, 2024
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  • 2024/2025
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  • nurs 5315 adv patho exam 2 set 2

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Nurs 5315: Adv Patho
Exam 2 Set 2 fully
solved & updated
2024-2025
Hemostasis - answer termination of bleeding


Two arms of hemostasis - answer Platelet plug formation
Coagulation cascade


Platelet Plug - answer *Primary response to bleeding
*a collection of platelets at the site of a damaged blood vessel that
helps slow or stop blood loss


Platelet Structure - answer Disc-shaped cells
1. peripheral zone: outer portion of the cell - cell membrane - made
of phospholipids
2. sol-gel zone: middle layer - contains structural support for the
cell
3. organelle zone - innermost layer - contains organelles


Four phases of platelet plug formation - answer Activation: injury--
>vWF, fibronectin, collagen, thrombospondin--> collagen activates
platelets--> platelets change shape to adhere to injury

,Adherence: platelets attach to injured endothelium-->vWF binds to
collagen and to the GP 1b/IX/V receptors on circulating platelets-->
anchors platelets in place
Aggregation: platelets bind to one another
Secretion: platelet granules release contents
Platelet plug is stabilized by fibrin and XIIIa which are end products
of the coagulation cascade


Normal WBC count - answer 5,000-10,000/mm3


Normal RBC count - answer Male: 4.7-6.1
Female: 4.2-5.4


Normal HgB - answer Men 14-18g/100mL
Females 12-16g/100mL


Normal Hct values - answer Male: 42-52%
Female: 37-47%


Normal MCV range - answer 80-100 cubic micrometers


Normal platelet count - answer 150,000-400,000/mm3


coagulation cascade - answer Secondary Hemostasis
The series of steps beginning with the intrinsic or extrinsic
pathways of coagulation and proceeding through the formation of a
fibrin clot to stabilize the platelet plug


extrinsic pathway of coagulation - answer initial coagulation
pathway that begins with tissue damage > Tissue Factor TF

, activates factor VII > results in the activation of the common
pathway


Intrinsic pathway of coagulation - answer Happens in blood vessels
when collagen fibers of the basement membrane are exposed to
blood


Collagen fibers of basement membrane -> Hageman factor (XII) ->
(XI) > (IX) > Stuart-Prower factor (X) -> Prothrombin (II) ->
thrombin -> fibrinogin (I) -> fibrin


tissue factor - answer protein thromboplastin, which initiates the
extrinsic pathway when released in response to tissue damage
cofactor for VIIa


Stable Factor, Proconvertin - answer Factor VII
VIIa forms complex w/ TF to activate factor X


Stuart-Prower factor - answer Factor X
Xa is component of prothrombinase complex which activates
prothrombin


prothrombinase complex - answer (Va, Xa, Ca++, PL), activates
prothrombin (II) > thrombin


prothrombin - answer Factor II
With prothrombinase complex converted to thrombin


Thrombin - answer converts fibrinogen to fibrin


Fibrinogen - answer with thrombin converts to fibrin

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