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Necrosis
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DIC*
thrombohemorrhagegulation
=:
Definition -DIC is an acute
,
subacute or chronic-
excessive actuation
-
characterized by
.
formation of thrombi in the micronasculature
=>
Occurs as 2
complication to
many
dis
-
Sometimes
coagulopathy localized to
specific organ tissue
.
is or
*
Ecology --DIL
:
is not a
"dy but rather is an
acquired congulopathy that
course clinical
may
occur in the
of a
variety of
cond
could activ
result
from porthologic ofcoagulation
·
o
↑
.
↑
impairment of clot-inhibiting
mechanisms
Pathogenesis
* : -
-
Trigger
·
2 mech DIC :
-
major
() Release
procorgulants
L
tissue
of factor or other
into the circulation
.
(2) endothelial cells
injury
.
Widespread of
() Procoagulants-tissue factor
variety of such
↳
be derived sources
can
from a
as
-
placenta in Ols complications .
↳ tissues trauma #
burns
.
↳ injured by or
Mucus released certain adenocarcinomas
from
↳ may also act as
procoay .
by directly activating
factor x)
(2) Endothelial
injury initiate DIC in several
:
can
-
.
ways
endothelial cell
Injuries that
-
cause necrosis
↓
the subendothelial matrice
expose
activ
leading to the platelets
of
Troagulation pathway
-
But subtle endothelial
injury
unleash
procoagulant activity
-
, even can
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