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CMB2004 Questions and Answer | Latest Update 2024/2025
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What is the specific/adaptive immunity? ~~> induced by exposure to an infection, very specific and has memory Describe the receptors in the specific immune response ~~> clonaly distributed, a large repitoire at a low frequency What is clonal selection? ~~> during development, cells re...

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  • September 15, 2024
  • 69
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • cmb2004 questions and answer latest update 2024
  • what is the specificadaptive immunity induce

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1 | P a g e | © copyright 2024/2025 | Grade A+




CMB2004 Questions and Answer |
Latest Update 2024/2025
What is the specific/adaptive immunity?


~~> induced by exposure to an infection, very specific and has memory




Describe the receptors in the specific immune response


~~> clonaly distributed, a large repitoire at a low frequency




What is clonal selection?


~~> during development, cells recognising self material are destroyed

leaving only those recognising non-self




Whats the role of clonal selection?


~~> reduces the repertoire leaving a pool of mature naive lymphocytes

which can proliferate and differentiate on activation to form effector cells




What are TCRs?


~~> T cell receptors, expressed by T cells and are always membrane bound




Master01 | September, 2024/2025 | Latest update

, 2 | P a g e | © copyright 2024/2025 | Grade A+


What do TCRs recognise?


~~> processed peptides on MHC on APC




What is this?


~~> TCR complex




What are the four domains of a TCR?


~~> heterodimer of alpha and beta




What can the four domains of a TCR sometimes be?


~~> gamma and delta




Whats CDR?


~~> complementary determining region




How many CDRs does a TCR have?


~~> each chain has 3 so 6 in total




Whats an MHC?




Master01 | September, 2024/2025 | Latest update

, 3 | P a g e | © copyright 2024/2025 | Grade A+


~~> essential for the acquired immune system to recognize foreign

molecules




What does MHC stand for?


~~> major histocompatibility complex




Whats different between MHCI and MHCII


~~> different structures and expression patterns presenting peptides from

different sources




How was MHC first discovered?


~~> in transplant rejection




Which cells are MHCI present on?


~~> all nucleated cells




What are the types of MHCI?


~~> HLA-A/B/C




What domains is the MHCI made of?



Master01 | September, 2024/2025 | Latest update

, 4 | P a g e | © copyright 2024/2025 | Grade A+


~~> alpha 1 2 3 and beta2 microglobulin




In MHCI, which domains are Ig-like?


~~> alpha 3 and beta2 micro globulin




In MHCI, which domains are polymorphic/peptide binding?


~~> alpha 1 and 2




What does MHCI bind with?


~~> CD8+ cells




Which cells are MHCII present on?


~~> APC/cytokine active cells




What are the types of MHCII?


~~> HLA-DQ/DR/DP




What domains is the MHCII made of?


~~> alpha 1/2 and beta 1/2




Master01 | September, 2024/2025 | Latest update

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