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CMB2004 Lecture 4 Questions and Answer | Latest Update 2024/2025
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Origin of haematopoietic stem cells? ~~> Bone marrow Site of B cell development to the stage of immature B cell? ~~> Bone Marrow what light chain is expressed first? ~~> kappa If BCR expressed by immature B cell binds to self cell surface antigen, the B cell is removed via? ~~>...

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  • September 15, 2024
  • 12
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • cmb2004 lecture 4 questions and answer latest u
  • origin of haematopoietic stem cells bone marr

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1 | P a g e | © copyright 2024/2025 | Grade A+




CMB2004 Lecture 4 Questions and
Answer | Latest Update 2024/2025
Origin of haematopoietic stem cells?


~~> Bone marrow




Site of B cell development to the stage of immature B cell?


~~> Bone Marrow




what light chain is expressed first?


~~> kappa




If BCR expressed by immature B cell binds to self cell surface antigen, the B

cell is removed via?


~~> negative selection




TF that haematopoeitic cells express leading to B cell development


~~> PAX5




Activated B cells in the periphery can develop into?




Master01 | September, 2024/2025 | Latest update

, 2 | P a g e | © copyright 2024/2025 | Grade A+


~~> plasma/memory cells




Which Ig chain is re-arranged first


~~> Heavy chain




What is the surrogate light chain


~~> produced by vpreB and gamma 5 to bind to H chain and make sure it

works




Which gene segments get re-arranged in the heavy/light chains?


~~> heavy= V/D/J, Light = V/J = Kappa/Lambda




Which stage of B cell development sees the most cell division


~~> Activation of B cells to produce plasma cells




what do the RAG 1 and 2 genes do and when


~~> Gene recombination, for Heavy/light chain rearrangement




what is the fate of a pre-B cell with non-productive rearrangements of the

light chain genes



Master01 | September, 2024/2025 | Latest update

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