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BIOCHEMISTRY CHAPTER 28 FATTY ACID SYNTHESIS Questions and Answers CA$19.59   Add to cart
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BIOCHEMISTRY CHAPTER 28 FATTY ACID SYNTHESIS Questions and Answers
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BIOCHEMISTRY CHAPTER 28 FATTY ACID SYNTHESIS Questions and Answers WHAT ARE THE RAW MATERIALS FOR FATTY ACID SYNTHESIS AND HOW ARE THEY OBTAINED? ACETYL COA IS THE BASIC SUBSTRATE IT IS TRANSPORTED OUT OF THE MITOCHINDRIA IN THE FORM OF CITRATE. AFTER THE FORMATION OF ACETYL COA, THE RESULTING ...

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  • October 2, 2024
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  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • biochemistry chapter 28 fatty acid synthesis quest
  • what are the raw materials for fatty acid synthesi
  • how are fatty acid synthesis and degradation coord

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BIOCHEMISTRY CHAPTER 28 FATTY
ACID SYNTHESIS Questions and
Answers
WHAT ARE THE RAW MATERIALS FOR FATTY ACID SYNTHESIS AND HOW ARE
THEY OBTAINED? - answer ACETYL COA IS THE BASIC SUBSTRATE
IT IS TRANSPORTED OUT OF THE MITOCHINDRIA IN THE FORM OF CITRATE.
AFTER THE FORMATION OF ACETYL COA, THE RESULTING OXALOACETATE IS
TRANSPORTED BACK INTO THE MITOCHONDRIA WITH A CONCOMITANT
FORMATION OF NADPH, THE REDUCING POWER FOR FA SYNTHESIS.
ADDITIONAL NADPH CAN BE GENERATED BY THE PPP. MAOLONYL COA , THE
ULTIMATE SUBSTRATE FOR FA SYNTHESIS IS FORMED BY THE
CARBOXYLATION OF ACETYL COA.

HOW ARE FATTY ACID SYNTHESIS AND DEGRADATION COORDINATED? -
answer MALONYL COA, THE SUBSTRATE FOR FA SYNTHESIS INHIBITS CAT I,
THUS PREVENTING THE TRANSPORT OF FA INTO MITOCHONDRIA FOR
DEGRADATION. PALMITOYL COA INHIBITS ACETYL COA CARBOXYLASE, THE
TRANSPORT OF CITRATE INTO THE CYTOPLASM, AND GLUCOSE6-PHOSPHATE
DEHYDROGENASE, THE CONTROLLING ENZYME OF THE PPP.

WHAT IS THE OVERALL STOICHIOMETRY FOR THE SYNTHESIS OF PALMITATE
FROM ACETYL COA? - answer 8 ACETYL COA + 7 ATP + 14NADPH --->
PALMITATE + 14 NADP + +8 COA + 6 H2O + 7 ADP + 7Pi

WHAT ARE THE THREE REACTIONS THAT ALLOW THE CONVERSION OF
CYTOPLASMIC NADH INTO NADPH?
WHAT ENZYMES ARE REQUIRED?
WHAT IS THE SUM OF THE 3 REACTIONS? - answer FIRST:
OXALOACETATE + NADH + H+ <---> MALATE + NAD+
(CATALYZED BY CYTOPLASMIC MALATE DEHYDROGENASE)
SECOND:
MALATE + NADP+ ---> PYRUVATE + CO2 + NADPH
(CATALYZED BY MALIC ENZYME)
THIRD:
PYRUVATE + CO2 + ATP + H2O ---> OXALOACETATE + ADP + Pi + 2H+
(CATALYZED BY PYRUVATE DECARBOXYLASE)
NET:
NADP+ + NADH + ATP + H2O---> NADPH + NAD+ + ADP + Pi + H+

, WHAT IS THE COMMITTED STEP IN FA SYNTHESIS AND WHICH ENZYME
CATALYZES IT? - answer THE FORMATION OF MALONYL COA FROM ACETYL
COA BY ACETYL COA CARBOXYLASE.

ATP-CITRATE LYASE - answer GENERATES CYTOPLASMIC ACETYL COA

MALIC ENZYME - answer HELPS TO GENERATE NADPH FROM NADH

MALONYL COA - answer ACTIVATED ACETYL COA

ACETYL COA CARBOXYLASE - answer CATALYZES THE COMMITTED STEP IN
FA SYNTHESIS

ACYL CARRIER PROTEIN - answer MOLECULE ON WHICH FA ARE
SYNTHESIZED

B-KETOACYL SYNTHASE - answer CATALYZES THE REACTION OF ACETYL
COA AND MAOLONYL COA

PALMITATE - answer THE END PRODUCT OF FA SYNTHASE

EICOSANOIDS - answer FA CONTAINING 20 CARBON ATOMS

ARACHIDONATE - answer A PRECURSOR OF PROSTAGLANDINS

AMP-DEPENDENT PROTEIN KINASE - answer INACTIVATES ACETYL COA
CARBOXYLASE

WRITE A BALANCED EQUATION FOR THE SYNTHESIS OF MYRISTATE. - answer
7 ACETYL COA + 6 ATP + 12 NADPH + 12H+ ---> MYRISTATE + 7 COA + 6 ADP + 6
Pi + 12 NADP+ + 5H2O

HOW MANY MOLECULES OF ATP AND NADPH ARE REQUIRED TO SYNTHESIZE
LAURIC ACID? - answer 6 ACETYL COA:
1 BECOMES 2 CARBONS FARTHEST FROM ACID END
5 GET CONVERTED INTO MALONYL COA
EACH MALONYL REQUIRES 1 ATP
5 ATP ARE REQUIRED
EACH ELONGATION REQUIRES 2 NADPH
10 NADPH ARE REQUIRED

ARRANGE IN PROPER ORDER

DEHYDRATION
CONDENSATION
RELEASE OF C16 FA

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