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Anki/Pathoma: Questions With Complete Solutions
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Anki/Pathoma: Questions With Complete SolutionsJaundice is a yellow discoloration of the skin and/or sclera
What is the earliest sign of jaundice? Right Ans - Scleral icterus
Jaundice is due to increased Right Ans - serum bilirubin , typically 2.5
mg/dL
Does hemolysis result in unconjugated or conjugated hyperbilirubinemia ?
Right Ans - Unconjugated
Hemolysis is associated with _____ urine due to increased urine urobilinogen
Right Ans - dark
Physiological neonatal jaundice occurs due to transiently low ______ activity at
birth Right Ans - UDP-glucuronyl transferase
Does physiological neonatal jaundice result in unconjugated or conjugated
hyperbilirubinemia ? Right Ans - Unconjugated
In physiological neonatal jaundice , unconjugated bilirubin deposits ______ ,
especially in the basal ganglia Right Ans - in the brain
________ is the deposition of bilirubin in the brain , especially basal ganglia,
causing neurologic deficits and possibly death Right Ans - Kernicterus
What is the treatment for physiologic neonatal jaundice ? Right Ans - non-
UV phototherapy
How does phototherapy treat neonatal jaundice ? Right Ans - Isomerize
UCB to water-soluble form
What is the mode of inheritance of hereditary hyperbilirubinemias (e.g.
Gilbert, Crigler-Najjar, Dubin-Johnson)? Right Ans - Autosomal recessive
_____ is due to mildly low UDP-glucuronyl transferase activity Right Ans -
Gilbert syndrome
, Gilbert syndrome presents with: Right Ans - jaundice during stress ,
illness , or fasting
Does Gilbert syndrome result in unconjugated or conjugated
hyperbilirubinemia ? Right Ans - Unconjugated
______ syndrome is due to absent UDP-glucuronyl transferase activity Right
Ans - Crigler-Najjar
Does Crigler-Najjar syndrome result in unconjugated or conjugated
hyperbilirubinemia ? Right Ans - Unconjugated
Crigler-Najjar syndrome causes ________ patients often die within a few years
Right Ans - jaundice and kernicterus early in life;
Which form of Crigler-Najjar syndrome is more severe ? Right Ans - Type I
What are the treatments (2) for Crigler-Najjar syndrome type I ? Right Ans
- plasmapheresis and phototherapy
Crigler-Najjar syndrome type II is _______ severe and responds to ________which
increases liver enzyme synthesis Right Ans - less; phenobarbital ,
________ syndrome is due to a deficiency of bilirubin canalicular transport
protein Right Ans - Dubin-Johnson
Does Dubin-Johnson syndrome result in unconjugated or conjugated
hyperbilirubinemia ? Right Ans - Conjugated
Dubin-Johnson syndrome presents with a _______, but is otherwise not
clinically significant Right Ans - grossly black liver
_______ is similar to Dubin-Johnson syndrome , but milder and Right Ans -
Rotor syndrome; WITHOUT black liver
Does Rotor syndrome result in unconjugated or conjugated
hyperbilirubinemia ? Right Ans - Conjugated
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