Exam (elaborations)

Hemostasis Part II - N5315 Advanced Pathophysiology, Hypersensitivities - N5315 Advanced Pathophysiology, Arachidonic Pathway - N5315 Advanced Pathophysiology, Solid Organ Transplant Rejection - N5315 Advanced Pathophysiology, AIDS - N5315 Advanced

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What is the 2nd arm of hemostasis? The coagulation cascade How many coagulation factors are there? 12 What are the coagulation factors made of? They are plasma proteins; most produced in the liver How are the coagulation factors named? Master01 | October, 2024/2025 | Latest update 1 | P ...

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Uploaded on October 12, 2024
Number of pages 85
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hemostasis part ii n5315 advanced pathophysiolo
what is the 2nd arm of hemostasis the coagulati

Institution N5315
Course N5315

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1 | P a g e | © copyright 2024/2025 | Grade A+

Hemostasis Part II - N5315
Advanced Pathophysiology,
Hypersensitivities - N5315 Advanced
Pathophysiology, Arachidonic
Pathway - N5315 Advanced
Pathophysiology, Solid Organ
Transplant Rejection - N5315
Advanced Pathophysiology, AIDS -
N5315 Advanced P... Questions
and Answers (100% Pass)
What is the 2nd arm of hemostasis?

✓ The coagulation cascade

How many coagulation factors are there?

✓ 12

What are the coagulation factors made of?

✓ They are plasma proteins; most produced in the liver

How are the coagulation factors named?

Master01 | October, 2024/2025 | Latest update

, 1 | P a g e | © copyright 2024/2025 | Grade A+

✓ In order of discovery.

What are coagulation factors in an inactive form?

✓ Zymogens

How is an activated zymogen noted as?

✓ With a after factor roman numeral (ex. Va is activated factor V).

What is considered the primary pathway of coagulation?

✓ Extrinsic pathway

When is the extrinsic pathway activated?

✓ When Tissue Factor is exposed at the site of injury

What is the process of the extrinsic pathway?

Master01 | October, 2024/2025 | Latest update

, 1 | P a g e | © copyright 2024/2025 | Grade A+

✓ Tissue Factor (III) exposed; binds with VII to form TF/VIIa complex;

TF/VIIa activates X-Xa; Xa binds with Va and calcium to form

prothrombinase complex; prothrombinase complex converts factor II

(prothrombin) to IIa (thrombin); IIa then activates 4 factors (I -

fibrinogen to Ia - fibrin; factors V, VIII and XIII); fibrin (Ia) placed over

platelet plug and XIIIa stabilizes the fibrin

Does a deficiency in factor XII (Hageman factor) cause bleeding?

✓ No

What is the main function of the intrinsic pathway?

✓ To enhance the extrinsic pathway

When is the intrinsic pathway activated?

✓ When the blood is exposed to negative charges which are found on

the molecules of ADP and ATP.

What is the process of the intrinsic pathway?

✓ Exposure activates XII (Hageman factor); XIIa then activates XI; XIa

activates IX; IXa then activates X; XA then forms the prothrombinase

complex in the common pathway

Master01 | October, 2024/2025 | Latest update

, 1 | P a g e | © copyright 2024/2025 | Grade A+

What must vitamin K dependent coagulation factors undergo in order to be a

functional protein?

✓ The process of carboxylation

When does carboxylation occur?

✓ Prior to the time a factor would be activated and is essentially part of

the maturation of the protein

What happens if vitamin K dependent coagulation factors do not undergo

carboxylation?

✓ They will not be functional proteins and cannot participate in the

coagulation process.

What is carboxylation?

✓ The change of glutamate to y-carboxygluatmate (which occurs after

the translation of glutamate) in the vitamin K dependent proteins

involved in the coagulation process.

What are the vitamin K dependent proteins?

Master01 | October, 2024/2025 | Latest update

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Exam (elaborations)

Hemostasis Part II - N5315 Advanced Pathophysiology, Hypersensitivities - N5315 Advanced Pathophysiology, Arachidonic Pathway - N5315 Advanced Pathophysiology, Solid Organ Transplant Rejection - N5315 Advanced Pathophysiology, AIDS - N5315 Advanced

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