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MNE- Pyruvate Dehydrogenase Exam Questions and Answers Rated 100%

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MNE- Pyruvate Dehydrogenase Exam Questions and Answers Rated 100% What are three diseases associated with low Pyruvate Dehydrogenase Complex function and what are their causes? - Answers 1) Wernicke's encephalopathy: thiamine deficiency 2) Beriberi: thiamine deficiency 3) Pyruvate Dehydrogenase...

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  • October 24, 2024
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MNE- Pyruvate Dehydrogenase Exam Questions and Answers Rated 100%

What are three diseases associated with low Pyruvate Dehydrogenase Complex function and what are
their causes? - Answers 1) Wernicke's encephalopathy: thiamine deficiency

2) Beriberi: thiamine deficiency

3) Pyruvate Dehydrogenase Complex Deficiency: genetic defect in PDC

What is the Pyruvate Dehydrogenase reaction? Where does it occur in the cell? - Answers Synthesis of
Acetyl-CoA + CO2 from Pyruvate

-pyruvate must be transported into mitochondrial matrix from cytosol

What are the 3 structural components of Coenzyme A? - Answers 1) Adenine + ribose-3-phosphate

2) Pantothenic acid central moiety

3) Mercaptoethylamine with *reactive thiol*

Which structures are involved in Acetyl CoA? - Answers 1) 2 carbons from Pyruvate are transferred to
*thiol group* of CoA

2) High energy thioester bond formed: Acetyl-CoA

Describe the thermodynamics of the Pyruvate Dehydrogenase reaction. - Answers 5 reactions: first is
irreversible, following 4 are reversible.

-Since 1st is irreversible, so is the entire process.

What are the 5 cofactors of the pyruvate dehydrogenase complex (PDC) and their vitamin precursors? -
Answers 1) Thiamine pyrophosphate (TPP): from thiamine

2) Flavin Adenine Dinucleotide (FAD): from riboflavin

3) Coenzyme A: from pentothenic acid

4) NAD+: from niacin

5) Lipoic acid: (no vitamin necessary)

What are the three enzymes of the PDC? - Answers 1) Pyruvate dehydrogenase (E1)

2) Dihydrolipoyl transacetylase (E2)

3) Dihydrolipoyl dehydrogenase (E3)

Describe the reactions that occur in PDC E1. - Answers 1) TPP + pyruvate --> hydroxyethyl-TPP + CO2

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