100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
MNE- Cholesterol Synthesis & Lipid Transport Exam Solutions Manual CA$11.48   Add to cart
Quickly navigate to
Preview
  2.  
  3. MNE- Cholesterol Synthesis & Lipid Transport
  4.  
  5. MNE- Cholesterol Synthesis & Lipid Transport

Exam (elaborations)

MNE- Cholesterol Synthesis & Lipid Transport Exam Solutions Manual
 5 views  0 purchase
  • Course
  • MNE- Cholesterol Synthesis & Lipid Transport
  • Institution
  • MNE- Cholesterol Synthesis & Lipid Transport

MNE- Cholesterol Synthesis & Lipid Transport Exam Solutions Manual What molecule is the central starting material for cholesterol synthesis? - Answers Acetyl-CoA Describe the structure of cholesterol (6 points) - Answers a) 27 Carbons (all from acetyl-CoA b) Three 6-C rings, one 5-C ring c) An ...

[Show more]

Preview 2 out of 5  pages

Document information

  • October 24, 2024
  • 5
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • mne cholesterol synthesis lipid transport

Written for

  • MNE- Cholesterol Synthesis & Lipid Transport
  • MNE- Cholesterol Synthesis & Lipid Transport

Seller

avatar-seller
TutorJosh

Reviews received

Content preview

MNE- Cholesterol Synthesis & Lipid Transport Exam Solutions Manual

What molecule is the central starting material for cholesterol synthesis? - Answers Acetyl-CoA

Describe the structure of cholesterol (6 points) - Answers a) 27 Carbons (all from acetyl-CoA

b) Three 6-C rings, one 5-C ring

c) An 8-C side chain at C17

d) Composed of isoprene units

e) 3' OH group is the only oxygen (*hydrophobic*

f) Double bond between C-5 & C-6 (delta-5)

What are three classes of compounds that isoprenes are precursors for? - Answers 1) Vitamins

2) Cholesterol

3) Steroid hormones

What are the 5 intermediate substrates during cholesterol synthesis? - Answers 1) Acetyl-CoA

2) Mevalonate

3) Isopentenyl Pyrophosphate

4) Squalene

5) Cholesterol

What are the 3 steps of cholesterol synthesis up to mevalonate? Why is this important - Answers 1) 2
acetyl-CoA --> acetoacetyl-CoA

2) A third acetyl-CoA added --> *HMG-CoA*

3) HMG-CoA --> mevalonate

a) 2 NADPH --> NADP+

b) carboxyl group reduced to OH

c) CoA Released



HMG-CoA --> mevalonate is a major regulatory step for cholesterol synthesis: *inhibited by statins*

, How do statins work in the cholesterol biosynthetic pathway? - Answers Resemble mevalonic acid, so
they competitively inhibit HMG-CoA Reductase

What are the 3 steps of cholesterol synthesis after mevalonate? - Answers 1) activated isoprenes made
by 3 sequential phosphorylations & 1 decarboxylation

a) yields d3-isopentenyl PPi + dimethylallyl PPi

b) 2 Pi added to C-5

c) Pi added at C-3, immediate decarboxylation of C1

d) Removal of C3 phosphate



2) Formation of Squalene

a) isoprenes fuse to form geranyl PPi

b) another isoprene added to form farnesyl PPi

c) 2 farnesyl PPi + NADPH --> Squalene



3) Conversion of Squalene to cholesterol

a) squalene - lanosterol - cholesterol (humans)

b) squalene - stigmasterol (plants)

c) squalene - ergosterol (fungi, yeast)

How is cholesterol stored within cells and transported in the blood? - Answers Within cells: fatty acyl-
CoA + cholesterol --> *cholesterol ester* via ACAT (Acyl-CoA-cholesterol acyl transferase)



In the circulation: cholesterol + Lecithin (PC) --> *cholesterol ester* via LCAT (lecithin-cholesterol acyl
transferase), transported via HDLs

What are ACAT and LCAT? - Answers Enzymes that convert cholesterol to cholesterol esters.



ACAT: Acyl-CoA-cholesterol Acyl Transferase (stores in cells)

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller TutorJosh. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for CA$11.48. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

67474 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling

Recently viewed by you

Class notes ·

(0)

EU Law- Free Movement of Persons

CA$11.48
  • (0)
  Add to cart