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MST Practice Exam Complete Questions With Well Defined Answers.
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Complete this sentence: A stringent test for_ __ is to inject cells into a host _ _ and examine their contribution to all tissues. - correct answer Pluripotency, blastocyst Which of the following statements accurately describes the process of generating inter...

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  • October 31, 2024
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  • 2024/2025
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MST Practice

Complete this sentence: A stringent test for_ __ is to inject cells into a host _ _ and examine their
contribution to all tissues. - correct answer Pluripotency, blastocyst



Which of the following statements accurately describes the process of generating interspecies chimeras
to harvest human organs? - correct answer Genetic complementation is used where
the host species blastocyst cells are deficient in a key gene to make a particular organ and the donor
pluripotent cells provide the missing key gene in order to make a donor-specific organ.



Which of the following statements CORRECTLY describes a function of the Polycomb protein? - correct
answer Polycomb binds to trimethylated histone 3 lysine 27 (H3Me27) where it acts
to repress transcription of nearby genes



Which of the tests for stem cell pluripotency is considered the most stringent? - correct answer
Tetraploid complementation



Which of the following is one of the stem cell niches of the adult brain? - correct answer
Subventricular zone



Which of the following is not a change that takes place during early reprogramming of mouse fibroblast
cells to generate iPS cells? : - correct answer Endogenous expression of Oct 4



Culturing in "2i + LIF" medium: - correct answer enabled derivation of ES cells from
rats.



Which of the following is NOT a characteristic of the molecular profile of stem cells - correct answer
Have low levels of telomerase activity



Stemness' is a concept based on the notion that there are: - correct answer
molecular signals common to all stem cell types.

, Complete this sentence: In cancers, bivalent genes in stem cells are DNA methylated and the state of
genome-wide methylation as the tumour progresses is: - correct answer
Hypomethylated



Complete this sentence: Calico cats are - correct answer always female and the coat
colour is due to random inactivation of X-chromosomes.



During kidney development the nephrogenic niche comprises the uretetic tip and which other tissue? -
correct answer The cap mesenchyme



Wounding of a zebrafish heart by cryoinjury - correct answer results in de-
differentiation of cardiomyocytes that proliferate and re-differentiate.



During unidirectional stem cell division, - correct answer both daughter cells
become progenitor cells.



Complete this sentence taken from Scadden's (2006) definition of the stem cell niche. ' The niche saves
stem cells from depletion, while protecting the host from over-exuberant ____________' - correct
answer stem-cell proliferation



Which of the following statements about adult stem cells is correct? - correct answer
Homeostasis can be achieved via a balance of symmetrical divisions that produce either stem cells or
differentiated cells.



In conventional mouse ES cells derived from the inner cell mass, fibroblast growth factor (FGF) added to
the medium: - correct answer promotes differentiation



Which of the following is NOT part of the functional definition for stem cells? - correct answer
Express common transcripts



When comparing naïve and primed epiblast cells which of the following is NOT CORRECT? - correct
answer Both cell types undergo proliferation when treated with LIF

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