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clinical sciences BM5CLS

in depth lecture material created using synchronous and asynchronous clinical science lectures which are re-used on a yearly bases! this module includes sub-sections of: intro to clinical sciences, haematology and transfusion science, medical biochemand cellular pathology. 21 lecture notes. buy thi...

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organ function testing

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• We're going to predominantly be looking at reference ranges, how they are used, how they are established, how effective they are in the healthcare environment specifically organ function testing. • The learning outcomes are, you have an appreciation for how biomedical scientists use biochemi...

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haematopoiesis

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• Haemopoiesis is a production of blood cells. • Haemopoiesis is a tightly regulated process that forms blood cells and haematology is a study of blood, and it involves the diagnosis and monitoring of diseases that are associated with blood and blood forming organs. • Blood cells are manufac...

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cardiac function testing

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• If we consider how you'd want to best approach a potential exam answer these are the kind of things you want to keep in mind when you are structuring your essay. • Why do we use biomarkers, what are they used for? They are used for diagnosis specifically they are used to manage a particular...

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haematology techniques and methods

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• All of haematology analysis is performed on blood or bone marrow. • The phlebotomist will use a torniquet and will do the sample by a technique called venepuncture, the blood is taken from the vein. • Blood clots really quickly so within two to five minutes it would form a clot and a fluid...

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liver function test

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• The liver is an organ about the size of a football, and it just sits under your rib cage on the right side of your abdomen. • It is essential for digesting food, ridding your body of toxic substances and therefore has an integral role in day-to-day physiology. • It is prone to disease and ...

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microcytic and macrocytic anaemia

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● We will focus on the general characteristics of anaemia and then I will go into detail on microcytic anaemia. ● Although anaemia is a primary pathological condition of the red blood cells there is a surprising lack of consensus on how it should be defined and the values that you find will a...

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renal function test

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preview summary:• There's a renal medulla and a renal cortex, the cortex tends to be outer region and the medulla is the more central region and the key structure within the renal medulla are the kidney nephron. • Top left – this is what the kidney nephron looks like, it consists of a bowman...

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thalassemia and sickle cell disease

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preview:● Haemoglobin is a tetramer made up of 4 globin polypeptide chains and each of them has a single haem group in the middle. ● When iron is bound to the oxygen the haem group is red in colour however when it lacks oxygen it is a blue and that's called deoxyhaemoglobin. ● Haem is made ...

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gastrointestinal tests

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preview:• The endocrine function is producing hormones but exocrine is producing digestive enzymes. • In the second portion will be looking at conditions associated with malabsorption of nutrients and there's quite a few of these. • In comparison to previous lectures where we've looked a...

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haemolytic anaemia

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preview:● We have extravascular and intravascular haemolysis. ● Extravascular – maybe the RBCs have a deformity in their shape and what can happen is that macrophages within the reticular endothelial system (e.g. the spleen), as blood is passing through the spleen, realise that those red cell...

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blood lipids

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preview• Major biomolecules alongside proteins, carbohydrates and nucleic acids and lipids planned number of different roles within the body. • They are an important structural component to cells, and you know that in relation to phospholipids with their hydrophilic head and their hydrophobic t...

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haemolytic disease of the newborn

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preview:• Levine and stepson discovered a postpartum woman who had delivered a stillborn foetus and an unusual case of intra-group agglutination was observed. She required post-partum blood transfusion and as a group O patient they transfused her with whole blood from her group O husband, she has ...

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laboratory organisation

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preview:• Pathology is there from the moment of conception all the way through to post-mortem. • We can see that in the genetic screening of babies before they are born when we can screen for down's syndrome for example and that's prior to a baby born so following conception all the way throu...

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haemostasis

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preview:• Haemostasis is coagulation. • 1 – of course, we want our blood to clot if we get an injury but why is it important that coagulation is only initiated when we get damage to a vessel wall, why is not a good thing if we were to bleed excessively and not control blood loss and why is it...

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sampling body fluid

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preview:• It is important to have an understanding of the different diseases we look at within medical biochemistry laboratories and the different diagnostic tests we perform but it is equally as important to understand the difference specimen types to understand which samples we require for which...

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coagulation disorders

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preview:● Glanzmann’s thrombasthenia – autosomal recessive so you have to inherit a faulty gene from mum and dad, and it is quite rare roughly around 1 in a million. ● Because it is an inherited condition patients will present with symptoms following birth therefore earlier in their life an...

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autoanalysers automation

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preview:• This lecture is about autoanalysers in relationship to biochemistry. • The clinical biochemistry laboratory is one of the most automated disciplines within pathology within BMS and because it performs the huge bulk of the entire workload received by the pathology department, it is imp...

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Point of care testing

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preview:• People who are living with diabetes generally use a small handheld device to monitor their blood glucose levels daily and therefore that's a form of point of care testing (POCT). • Why we have implemented POCT in some particular areas for some particular tests. • To provide exam...

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overview of the NHS blood and transplant service

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preview:• They are unusual in that the natural occurring antibodies occur in the plasma of subjects who lack the corresponding antigen even if they’ve never been transfused or been pregnant. • The most important of these are anti-A and anti-B, they are usually IgM and react optimally at cold ...

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transfusion reactions

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preview:• Cross matching forms a key component of blood transfusion – it is ultimately what we do – we are gong to make sure the blood we give to a patient form the donor is compatible. • Many reasons when a blood transfusion is required form being involved in a road traffic accident or sur...

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