Lecture notes
Lecture Notes
- Institution
- Queen Mary, University Of London (QMUL)
Lecture notes of 10 pages for the course Cell Biology and developmental genetics at QMUL
[Show more]
1 review
By: betulalm • 3 year ago
Content preview
Actin, microtubules, cell-cell junction and cell polarisationLearning objectives
1. Cytoskeleton
2. Actin
3. Microtubules
4. Intermediate filament
5. Cell-cell junction
Maintenance of tissue architecture: small intestine
Image shows communication between cells is vital for maintance of tissue architectures.
Stromal cell secretes GF to communicate with the epithelial cells
The cytoskeleton is vital for cells to change and maintain shape
Cytoskeleton is dynamic
Cell migration
l- cytoskeleton
, 3 kinds of filaments:
1. Microtubules
2. Actin filaments
3. Intermediate filament
Functions of the cytoskeleton:
- Structure
- Attachment
- Compartmentalisation
- Motility
- Transport
- Cell division
Filamentous network that provides the structural framework of cells
Actin filaments Microtubules Intermediate filaments
Thin 25nm 8-10 nm
Microfilaments Thickest Less dynamic than actin and
6nm Highly dynamic like actin microtubules
The cytoskeleton is highly dynamic, it changes during change in cell shape
Image mainly represents actin and microtubule
Stat with small soluble subunit
- For actin, the small soluble subunit is called G-actin
- For microtubule, the small soluble subunit is called tubule
The small soluble subunit then self-assembles to form large filamentous polymer
GF trigger disassembly of filaments and rapid diffusion of subunits
Followed by reassembly of filaments at a new site to maintain cell polarity or structure of tissue
The cell responds rapidly to the GF by changing shape or migration
Microscopic image of cells
- The molecule, tubulin has been conjugated with rhodatin that has been introduced to the cell
- Therefore, the tubulin has been incorporated into the microtubule
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller fatima-attia. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £2.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67866 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now