Lecture notes
Prescribing in patients with liver disease
- Module
- Pharmacy (MPHARM)
- Institution
- University Of Hertfordshire
Prescribing in patients with liver disease - summary of the liver, liver disease and prescribing in these patients
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Prescribing in special groups - liverdisease - 6.12
⚡ Learning outcomes:
Describe the anatomy, physiology, and functions of the liver.
Describe and interpret liver function tests (LFTs).
Discuss the pathophysiology, signs and symptoms of liver disease.
Discuss the detrimental effect of pharmacotherapy on the liver.
Discuss the risk mitigation concerning detrimental impact of pharmacotherapy on the liver.
⚡ The liver:
One of the largest internal organs in the body
Liver disease can be a major killer
Drugs cause about 20-30% of acute liver failure cases
The liver has a pivotal role to play in drug metabolism
⚡ Liver anatomy:
Prescribing in special groups - liver disease - 6.12 1
, A very vascular Blood supply:
portal vein - delivers 80% of liver’s blood
hepatic artery - 20% of livers blood supply
Hepatocytes: basic metabolic liver cells of the body
⚡ Functions of the liver:
Storage: vitamins, glycogen
Homeostasis: glucose
Secretion: bile salts
Excretion: cholesterol
Synthesis: albumin (protein-bound drug examples??), clotting factors
Metabolism: vitamin D
Filtration: antigens
Prescribing in special groups - liver disease - 6.12 2
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