Summary
Summary Renal therapeutics and aki
- Module
- Mpharm (PHAR22001)
- Institution
- The University Of Manchester (UOM)
summary of renal therapeutics and how nephrotoxic medicines can impact patients and patients with existing AKI.
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Renal Therapeutics and AKINephrotoxic medicines
Some medicines can cause kidney damage.
By altering kidney function:
o Direct toxicity: damaging kidney cells
o Blood flow disruption
o Renal tubular damage
o Crystal formation: crystals form and obstruct the flow of urine.
o Immune-mediated reactions: inflammation
o Altered electrolyte balance: e.g., diuretics cause imbalances.
o Metabolic effects of drugs: toxic metabolites.
Patients at risk
Over 60
Underlying renal impairment
Volume depletion
Diabetes
Sepsis
Heart failure
Preventative measures
Non-nephrotoxic medicines
Correcting risk factors
Ensure baseline renal function before starting on these.
Monitor renal function.
Avoid combinations of nephrotoxic medicines
Awareness
Help you identify possible medical causes of renal failure.
Ensure further nephrotoxic medicines are not further prescribed.
Appropriate dosage adjustments
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