Exam (elaborations)
UNE MEDICAL BIOCHEMISTRY MIDTERM REVIEW QUESTIONS AND ANSWERS.
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- Oxford University (OX)
UNE MEDICAL BIOCHEMISTRY MIDTERM REVIEW QUESTIONS AND ANSWERS.
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UNE MEDICAL BIOCHEMISTRYMIDTERM REVIEW QUESTIONS AND
ANSWERS
Ribose and NADPH - answer A family presents for genetic counseling. The couple has two
female children who are alive and well; however, their infant son recently died in the nursery
with severe hemolysis (lysis of red blood cells) and jaundice. The wife recalls she lost a brother
in infancy with severe hemolysis, induced after a viral infection. The physician suspects a
glucose-6-phosphate dehydrogenase deficiency, this would result in a deficiency in which of the
following compounds in red blood cells?
Transketolase - answer A patient presents to the emergency department with lactic acidosis. A
deficiency in thiamine (TPP) is suspected and this will be consistent with a decrease in the
activity of following enzymes?
UDP-Glucose - answer Galactose 1-phosphate is initially converted to glucose 1-phosphate and
requires which of the following compounds?
Thiamine diphosphate - answer Which of the following cofactors is required for transketolase
activity?
Glyceraldehyde 3-phosphate - answer Aldolase B facilities a reaction that cleaves fructose 1-
phosphate into two 3-carbon molecules that will enter glycolysis as which of the following
compounds?
Glycolysis - answer High levels of activity of the non-oxidative portion of the pentose phosphate
pathway will directly produce intermediates of which of the following pathways?
Glucose 6-phosphate dehydrogenase - answer The major regulatory step of the pentose
phosphate pathway is catalyzed by which enzyme?
, VLDL particles - answer Insulin stimulates fatty acid synthesis in the liver. These fatty acids are
transported to the adipose tissue as which of the following?
Free fatty acids - answer A young woman goes to work without eating breakfast and skips lunch.
In this scenario, which of the following pathways is providing substrates used to generate ATP in
the liver?
Glucagon - answer Caffeine is a natural inhibitor of phosphodiesterase. If you were to consume
a large amount of coffee you would likely see a prolonged response to which of the following
stimulants or hormones?
They enhance transcription when bound to receptors - answer A teenage female presenting
with lack of menstruation (amenorrhea) is found to have a dysfunctional steroid receptor
characteristic of androgen insensitivity syndrome. Which of the following statements accurately
describes steroid hormones?
Intracellular receptors - answer Steroid hormones bind which of the following types of
receptors?
They are specific to a chemical messenger - answer Which of the following is a characteristic of
all receptors?
Free fatty acids - answer What is the primary oxidized fuel for skeletal muscle in the fasted
state?
Cyclic-AMP response element binding protein (CREB) - answer cAMP elicits multiple cellular
responses. The effects of cAMP on gene transcription are directly mediated by which of the
following DNA binding proteins?
GLUT4 - answer An individual is recently diagnosed with Type 2 diabetes. In this individual,
hyperglycemia may in part be due to inactivity of which of the following glucose transporters on
skeletal muscle?
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