100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Cells and Development (CELL0007) Notes - Cell Signalling £6.49
Add to cart
Quickly navigate to
Preview
  2.  
  3. University College London (UCL)
  4.  
  5. Cells and Development (CELL0007)

Lecture notes

Cells and Development (CELL0007) Notes - Cell Signalling
 0 purchase

Explore cell signalling with these specialized notes tailored for Year 1 students in the Cells and Development (CELL0007) module at University College London. Immerse yourself in the complexities of cell signaling, navigating the pathways of signaling through ion channels, deciphering the nuances o...

[Show more]

Preview 3 out of 26  pages

Document information

  • November 30, 2023
  • 26
  • 2020/2021
  • Lecture notes
  • Dr amanda cain
  • All classes

Subjects

Written for

All documents for this subject (3)

Seller

avatar-seller
sujansathiendran

Reviews received

Content preview

Signalling Through Ion Channels
Signalling Through Ion Channels
Distribution of ions in gradients
• Membranes are normally impermeable to ions
• Cells have evolved ways of transporting ions across membranes
o Channel protein




▪
o Carrier protein




▪
• Ions are distributed in gradients




o




o
• Ion transport can be passive or active




o
• Passive ion transport is determined by the electrochemical gradient

,Signalling Through Ion Channels




o
• Summary
o Ions exist in gradients across both the PM and organelles
o Ion transport is effected by transporters and ion channels
o Transport can be passive or active

How ion gradients are generated ways
• Ion gradients are generated by active transport
o Active transport requires ATP




▪
• Ions are distributed in gradients
o Na / K gradient




▪
▪ Na/K pump generates Na and K gradients across the plasma membrane




•
o Pump embedded in membrane
o ATP → ADP + Pi
o 3Na ejected out of cell + 2K brought into cell = generating Na and K gradient
▪ Na – higher concentration outside
▪ K – higher concentration inside
• Na/K pump = P-type ATPase (phosphorylation)

, Signalling Through Ion Channels




o
o Pump phosphorylated in response to ATP hydrolysis
▪ Resting state
• Pump in particular confirmation – with binding site for 3Na
▪ ATP hydrolysed to ADP
• Phosphorylates pump
▪ Confirmational change = Na ions leave cell
▪ 2K ions bind to new confirmation
▪ Pump is dephosphorylated
• Phosphate unbinds
▪ K ions enter cell
o Ca gradient




▪
▪ Ca pumps generate Ca gradients across the plasma membrane




•
•
Plasma membrane Ca ATPase (PMCA) – P-type ATPase
o Phosphorylated = active – transports Ca out of cell
▪ Ca pumps generate Ca gradients across intracellular stores

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller sujansathiendran. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £6.49. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

69052 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 15 years now

Start selling
£6.49
  • (0)
Add to cart
Added