BIOS 286 EXAM 3- Plasticity, Learning, And Memory Verified Solutions

BIOS 286 EXAM 3- Plasticity, Learning, And Memory Verified Solutions the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activitysynaptic plasticity synaptic plasticity Plasticity is the OUTCOME of ________ and __________ changes. molecular structural What are the 2 types of synaptic plasticity? long term potentiation long term depression an increase in a synapse's firing potential after brief, rapid stimulation. Believed to be a neural basis for learning and memory. long term potentiation the long-lasting decrease in the strength of synaptic transmission long term depression t/f: tboth LTP and LTD represent the outcomes of cellular mechanisms employed by various neuronal networks t New neural pathways and modification of existing pathways plastic changes In the beginning plasticity was called neuronal _____________ modifability ___ is considered one of the most important forms of plasticity in the nervous system. LTP LTP is heavily studied in the ________ where Schaffer collaterals (from CA__ pyramidal neurons) synapse onto CA__ pyramidal neurons These are ________ excitatory synapses. hippocampus 3 1 glutamatergic t/f: The synaptic network of the hippocampus is well known and relatively simple. t a neural center located in the limbic system; helps process explicit memories for storage; learning am memory hippocampus the hippocampus is located in the _______ region of the ________ lobe medial temporal AGAIN: LTP is heavily studied in ____________ brain slices. SC - Schaffer collaterals - processes from CA___ _______ neurons, which synapse onto CA__ __________ hippocampal 3 pyramidal 1 neurons an area of the medial temporal cortex that is a major source of neural signals to the hippocampus entorhinal cortex t/f: EC inputs are from temporal, orbital, olfactory cortices, and amygdala. t EC outputs mainly to ________ and nucleus __________, also ________ areas. amygdala accumbens cortical LTP: In synapses, which can undergo LTP, _______ and repetitive stimulation can lead to the induction and persistence of LTP. strong LTP: Hippocampal plasticity requires coincidental activation of both pre- and post-________ parts synaptic LTP: Hippocampal plasticity is ________ - dependent. Plasticity in other brain areas has also been shown to be NMDAR-dependent. NMDAR an ion-channel receptor found at most excitatory synapses NMDAR LTP: The increased postsynaptic responses have ______ (e.g. formation of additional postsynaptic sites) and _______ (protein synthesis, signaling, etc.) foundations cellular molecular NMDAR - mediated LTP in hippocampus - NMDARs require two events to occur in order to be activated - ________________ has to bind to NMDARs - The cell membrane has to _______ enough to eject the ____+ ion which plugs in the pore of the