Learning Objectives:
Discuss the fundamental need for the immune system.
Identify physical and chemical barriers against pathogenic invasion.
Describe mechanisms of immune invasion by pathogens.
Predict the outcome of scenarios of immune deficiency.
Summarize the key features of innate and adaptive immune responses.
Describe antigen-antibody interactions.
Classify immune cell types by their role in responses.
Define immunological memory and its importance.
Introduction:
Immunity refers to the body's ability to defend itself against disease and infection. Immunity can
be categorized into two different forms: innate or adaptive. We will explore the 2 types of
immunity. Have you ever wondered what infections look like from the pathogen’s perspective? If
our immune systems are so amazing, why do we get sick at all? The immune system is a
complex army of cells and tissues that work together to protect your body from infection. In this
simulation, you’ll play the part of a pathogen and try to establish an infectious colony within a
human body. You will come face to face with the major cells and organs of the immune system.
As the immune system fights back, you will gain a unique perspective on how immune cells
work to destroy incoming pathogens.
By exploring data maps from pivotal moments in human history you will see how an individual’s
immunological status contributes to the health of their community and the spread of disease
worldwide. You’ll meet the key cells involved in immune memory and explore the role of
immunization in protecting people from preventable diseases. You will undertake a series of
challenges in preparation for an important global health investigation.
Assignment:
Part 1 Labster “Introduction to Immunology: Explore the immune system and save the world”
As you complete the lab, have the lab report ready to record data. The theory section is a
helpful resource.
Part 2 Complete the lab report.
, Immune System Lab Report
1. Describe components of the immune system by completing the following chart (see
theory):
(½ point each for total of 3.5 points)
Description/Function
Physical and chemical barrier, born with this, it is non-specific
to attacking pathogens, For Example Skin, Mucous
Membranes, NK Cells, and Phagocytes.
Innate immunity
Immunity that is acquired overtime, cell mediated immunity (t
cells) and antibody mediated immunity (b cells)
Adaptive immunity
This is the most abundant antibody, the only antibody that can
cross placenta to protect newborn through breast feeding.
Exposed to the same type of virus/ cell can lead to an
IgG increase in abundance to a second exposer.
B-mediated immunity (prior to sufficient IgG) Forms anti-A and
anti-B receptors of the ABO blood group system. Found in
blood and lymph. Triggers the complement system =
IgM agglutination, and lysis of microbes.
This is found in the secretion of the saliva, mucus, and tears.
Levels of decrease during stress, increasing chances of
infection. Provides localized protection against infection.
IgA
Responsible for allergic reaction = most powerful reaction,
found in blood and lymph. Triggers the complement system
binds to allergens and triggers histamines release from mast
IgE cells and basophils. Protects against parasite worms.
Thymus Pre cursor T-cells develop, differentiate, and multiply, as well
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