Lecture notes

Lecture Notes for Brain Aging

0 purchase

Module
Biology of Ageing (6BLBL0325)

Institution
Kings College London (KCL)

Complete and revised notes from lectures original lecture notes that have been made more concise and descriptive, according to the learning objectives described for exams.

[Show more]

Preview 1 out of 3 pages

View example

Uploaded on June 5, 2024
Number of pages 3
Written in 2023/2024
Type Lecture notes
Professor(s) Richard siow
Contains All classes

£5.56

Add to cart

Add to wishlist

100% satisfaction guarantee
Immediately available after payment
Both online and in PDF
No strings attached

Objectives:
1. Global impact of brain aging
2. Concept of adult neurogenesis
3. Different locations of adult neural stem cells and their neurogenic niche in
mammalian brains
4. One example of molecular control of adult hippocampal neurogenesis
5. Possible functions of adult hippocampal neurogenesis
6. Impact of aging on hippocampal neurogenesis
7. Impact of environmental factors on hippocampal neurogenesis

GLOBAL IMPACT:
- 2050 = estimated population of 2 billion people 60+ years old
- 2050 = estimated 130 million people will have dementia
- Over 65 year old  risk of dementia doubles every 5 years
- Dementia and cognitive decline are in a cycle with the fundamental mechanisms of
brain aging
- Fundamental mechanisms that age the brain  cognitive decline
- Cognitive decline  increases mechanisms that age the brain
- Genetics, education, occupation, environmental, health and available health care
impact the ways we age
- Interventions must prevent or delay cognitive aging + dementia
- Focus for intervention = targeted altered neurogenesis
- Can also look at vulnerabilities (diabetes, early-life stress, obesity etc.) and other
cellular mechanisms (inflammation, impaired DNA repair etc.) to aid intervention

ADULT NEUROGENESIS:
- Process where neurones are generated from neural stem cells in the adult brain
- Different to prenatal neurogenesis
- Was assumed that neurogenesis was not possible, until found evidence of postnatal
hippocampal neurogenesis in rats
- Limited to specific brain regions
o Subventricular zone of lateral ventricles
 New neurones from this region project into olfactory bulb
 Mostly evident in rodents (not humans) – likely because rodents rely
on the olfactory bulb much more heavily
o Subgranular zone of dentate gyrus (in hippocampus)
 New neurones from this region project into the CA3 region
 CA3 region of brain = role in memory processing + neurodegeneration
 Demonstrated in rodents
- Neural stem cells in dentate gyrus proliferate, migrate + differentiate to have
projections that extend out of dentate gyrus
- Projections join + innervate CA3 region through mossy fibre pathway between
dentate gyrus and CA3
- CA3 neurones innervate CA1 neurones  CA1 neurones innervate entorhinal cortex
 entorhinal cortex innervates neocortical associated areas + dentate gyrus
o All confirmed in rodent studies

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller sadiecopperthwaite. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £5.56. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

67479 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 15 years now

Start selling