100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Lecture notes BIOS5030 Cell Biology (BIOS5030) on The Membrane and protein movement (part 2) £10.49   Add to cart

Lecture notes

Lecture notes BIOS5030 Cell Biology (BIOS5030) on The Membrane and protein movement (part 2)

 5 views  0 purchase

Unlock your academic potential with my notes on Cell Biology, tailored specifically for students pursuing Biomedical Science, Biochemistry, Biology, Biomedical Engineering, Pharmacology, Cell Biology, Medicine and Nursing. These notes are perfect for anyone looking to excel in their studies and gai...

[Show more]

Preview 1 out of 4  pages

  • June 13, 2024
  • 4
  • 2023/2024
  • Lecture notes
  • Dr gourlay, mulvihill, shepherd, mulligan, goult
  • All classes
All documents for this subject (18)
avatar-seller
morgan_helene
Week Number: 12
Seminar Date: Friday 27th October
Time: 12pm – 1pm
Module: Cell Biology BI503

The Membrane and protein movement continued…

Membrane protein movement is often restricted in several ways:

1) Cytoskeleton interactions – red blood cells interact with the sceptrin meshwork. This allows
red blood cells to form a strong meshwork across the membrane, making them strong
enough withstand forces within the blood vessels.

Membrane proteins modify the organisation and structure of a membrane. (image) 3 ways in
which non transmembrane proteins can bend membranes:

1) Reticulons – hydrophobic domains inserted into one leaflet of membrane.
2) Nips for the nuclear pore – proteins form rigid scaffold on one side of the membrane
causing curvature of the membrane.
3) Proteins that interact with specific lipids i.e. large headgroup lipids like phosphoinositide.

Example: ATP synthase aggregates which restricts its movement and changes the structure of the
membrane to form tubes and different shapes. Not only do the membranes influence the proteins
but the proteins also influence the membranes i.e. TMEM16 can thin the membrane to allow for
more efficient scrambling.

Research Highlight: probing the mechanism of a transporter associated with human metabolic
disease.

Membrane proteins are important for cellular functions and understanding what they look like.
How they function is key to:

1) Treating diseases associated with malfunction of proteins i.e. CFTR (cystic fibrosis)
2) Targeting proteins for inhibition in the prevention of diseases i.e. multidrug efflux pumps
3) Targeting proteins to improve human health and healthcare I.e. understanding pain signaling
by TRP channels.

RECAP of: Transporters, the functional characterisation of vsINDY and mechanisms associated to
this.

Membrane transport: membranes are selectively permeable. The gate keepers for this process are
channels (holes in the membrane that are gated, when open they have fast transport rates) and
transporters (much slower and enhance electro transferase gradients which help with transport).

Active transports:

1

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller morgan_helene. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £10.49. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

81113 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now

Start selling
£10.49
  • (0)
  Add to cart