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Management of Cholesterol Questions and answers
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Management of Cholesterol Questions and answers 3. How do statins work?: up regulate LDL receptors 4. What are the high intensity statins: atorvastatin rosuvastatin 5. What are the moderate intensity statins: atorvastatin rosuvastatin simvastatin

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  • August 18, 2024
  • 7
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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Management of Cholesterol
Questions and answers




1. What is the 1st line treatment for hyperlipidemia in all patients without contraindications?: Statin
therapy

2. What roles do statins play in the body?: anti-inflammatory, antioxidant, an- tithrombotic effects

3. How do statins work?: up regulate LDL receptors

4. What are the high intensity statins: atorvastatin rosuvastatin

5. What are the moderate intensity statins: atorvastatin rosuvastatin

simvastatin

6. What are the low intensity statins: simvastatin

7. What is second line option for hyperlipidemia?: ezetimibe

8. How does ezetimibe work?: inhibits cholesterol absorption in small intestine

9. Ezetimbe lowers cholesterol by lowering what?: LDL (18-20%)

10.Ezetimibe is not useful for what: low HDL or high triglycerides

11.What are adverse reactions of ezetimibe?: slight increase in LFT when used with statins, very little risk of
myopathy

12.What is a disadvantage of ezetimibe?: -effects LDL only

-should not be used as monotherapy (use with statin)

-probably does not have the same effect on mortality as statins do

13.What is the indication for PCSK9 inhibitor use?: heterozygous familial hyper- cholesteremia and ASCVD risk
unable to control by statin alone

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7

, Management of Cholesterol
Questions and answers
14.What is a PCSK9 inhibitor recommended to take with?: statin

15.What is the PCSK9 inhibitor mechanism of action?: Blocks degradation of LDL receptors on the liver, which
leads to increased clearing of LDL

16.How much can a PCSK9 inhibitor lower LDL?: 45-64%

17.What do we have to monitor when giving PCSK9 medications?: LDL levels

18.What are some adverse effects of PCSK9?: - injection site reactions

- upper respiratory symptoms

- flu like symptoms

19.What are 4 ASCVD statin benefit groups?: 1. Clinical ASCVD

2. LDL >190

3. Diabetes (45-75 yrs) with LDL 70-189

4. LDL 70-189, no diabetes or ASCVD, 10 year risk >7.5%

20.For patients who are very high risk, what needs to be tried prior to starting PCSK9 inhibitor?: maximally
tolerated statin

21.What is the LDL goal for patients at very high risk? What if it is above this number?: <55; reasonable to try
ezetimibe to lower LDL to <55




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