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PC 707 Final Safety Exam Questions And Complete Answers
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PC 707 Final Safety Exam Questions And Complete Answers What Black Box Warning does Carbamazepine & Lamictal carry? Potential lifethreatening dermatologic reaction, including Steven's Johnson and Toxic Epidermal Necrolysis What Black Box Warning does Promethazine (Phenergan) antiemetic carry...

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  • October 13, 2024
  • 17
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • pc 707 final safety exam
  • questions and complete answers

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  • PC 707
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PC 707 Final Safety Exam Questions And
Complete Answers

What Black Box Warning does Carbamazepine & Lamictal carry? Potential life-

threatening dermatologic reaction, including Steven's Johnson and Toxic Epidermal Necrolysis




What Black Box Warning does Promethazine (Phenergan)


antiemetic carry? Potential for life threatening respiratory depression in children.




What Black Box Warning do Fluoroquinolones carry? Potential for tendon rupture




What Black Box Warning does SSRIs carry? Potential increased risk of suicide in teens.




What Black Box Warning does opioids carry? Combining opioids & benzodiazepines can

cause extreme sleepiness, slowed breathing & death




Insulin/Sulfonaureas adverse effect Hypoglycemia!




Tricyclic Antidepressants Very risky for overdose

, PC 707 Final Safety Exam Questions And
Complete Answers

Nitrofurantoin (Macrobid) adverse effect Pulmonary Toxicity (rare )




Proton Pump Inhibitors Increases the risks for ‣ Upon starting: Community acquired

pneumonia

‣ Over time more likely to get infections like TB

‣ Over time possible increased potential for fractures




Bisphosphonates potential risk osteonecrosis of the jaw




As we age, our kidneys become smaller & there is a decrease in renal blood flow. Why is this a

prescribing consideration? Decreased renal clearance of drugs




As we age, our liver become smaller, has decreased blood flow & first pass metabolism

decreases. Why is this a prescribing consideration? Decreased liver size also means

decreased production of CYP 450 enzymes!

So if you need to select a drug for the elderly, try to select drugs that use Phase 2 metabolism

(not affected by age) Phase I is affected & involves the CYPs.

, PC 707 Final Safety Exam Questions And
Complete Answers

AS we age, there is a decrease in total body water by 10-15%! Why is this a concern when

prescribing for the elderly? Decrease in total body water results in decreased distribution

of water soluble medications & causes increased serum levels of drugs.




Why are the elderly at higher risk of Torsades de Points? Elderly tend to be on more

drugs, so more of a chance to have multiple QT prolongation drugs.

Additional risk of TdP with low potassium, *low magnesium* & bradycardia- more common in

the elderly.

Afib more likely




What are the concerns with anticholinergic drugs & the elderly? In the elderly

Anticholinergic drugs can cause:

‣ Memory impairment,

‣ confusion,

‣ falls,

‣ hallucinations,

‣ tachycardia &

‣ acute angle glaucoma

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