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PHA 430 Exam 1 Questions & Answers 2024/2025
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PHA 430 Exam 1 Questions & Answers 2024/2025 _______ are any agent inducing an immune response. - ANSWERSimmunogens ________ are any agent capable of binding specifically to components of immune response. - ANSWERSantigens Carbohydrates, lipids, and nucleic acids are _______ antigens. - ...

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  • October 24, 2024
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  • 2024/2025
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PHA 430 Exam 1 Questions & Answers
2024/2025

_______ are any agent inducing an immune response. - ANSWERSimmunogens



________ are any agent capable of binding specifically to components of immune response. -
ANSWERSantigens



Carbohydrates, lipids, and nucleic acids are _______ antigens. - ANSWERSweak



Proteins are _______ antigens. - ANSWERSstrong



What is the difference between an antigen and immunogen? - ANSWERSAn antigen may or may not
induce an immune response while an immunogen will always produce an immune response



Thymus (dependent or independent) antigens produce a B and T cell response. - ANSWERSdependent



Thymus (dependent and independent) antigens produce a B cell response only. - ANSWERSindependent



The Fab portion of an antibody is for what? - ANSWERSbinding



The Fc portion of an antibody is for what? - ANSWERScrystallization



What are the functions of IgG? - ANSWERS- agglutination, precipitation, and opsonisation

- conferral of immunity to fetus

- ADCC (antibody dependent cell mediated cytotoxicity)

- activation of complement

- neutralization of toxins and viruses

,- immobilization of bacteria



IgM has _____ binding sites - ANSWERS10 (pentamer)



A large amount of IgM is produced after ________. - ANSWERSvaccination



IgM is produced in response to ____________antigens. - ANSWERSthymus independent



High levels of _______ indicate recent infection. - ANSWERSIgM



What are some benefits to the large size of IgM? - ANSWERS- will not cross placenta

- remains in blood

- best antibody for blood infections because of large binding sites



Elevated levels of IgM in a fetus indicates what? - ANSWERScongenital infection



What aspect of IgM makes it great at agglutination? - ANSWERSit has 10 binding sites



Where is IgM synthesized? - ANSWERSplacenta



What is the major immunoglobulin found in secretions? - ANSWERSIgA



What immunoglobulin has a role in mucosal infections? - ANSWERSIgA



IgA has _________ activity. - ANSWERSbactericidal and antiviral



_______ is present on the surface of B lymphocytes and causes the differentiation of B cells to a more
mature form. - ANSWERSIgD

,What immunoglobulin protects against parasites? - ANSWERSIgE



________ has an important role in hypersensitivity. - ANSWERSIgE



The IgE receptor is on______ cells. - ANSWERSmast



(Secondary or Primary) response has a shorter lag phase and an extended plateau and decline. -
ANSWERSsecondary



The antibody titer is greater in a ________ response. - ANSWERSsecondary



(Secondary or Primary) response consists of exposure to a new antigen, prolonged lag phase, small
amount of IgG present and more IgM, a small plateau, and rapid decline. - ANSWERSPrimary



(IgG or IgM) is more prevalent in a secondary response. - ANSWERSIgG



Where do T cells develop? - ANSWERSthymus



Where do B cells differentiate? - ANSWERSfetal liver and adult bone marrow



______ cells do not possess T or B cell receptors. - ANSWERSNK



What is a major difference between B and T cells? - ANSWERSB cells do not go through the thymus



(B or T) cells secrete antibodies. - ANSWERSB



What is the definitive T cell marker? - ANSWERScell antigen receptor (TCR)



Which T cell receptor is composed of gamma and delta chains? - ANSWERSTCR-1

, Which T cell receptor is composed of alpha and beta chains? - ANSWERSTCR-2



Both TCR receptor are associated with complex of polypeptides making up the ______ complex. -
ANSWERSCD3



Which T cell receptor is more prevalent? - ANSWERSTCR-2



CD3 is responsible for ___________ - ANSWERSsignal transduction



What chains made up CD3? - ANSWERSzeta, gamma, delta, gamma, delta, zeta



TCR-2 cells are divided into what two subsets? - ANSWERSCD4+ and CD8+



CD4+ are also referred to as ___________. - ANSWERSHelper T cells



CD8+ are also known as - ANSWERScytotoxic T cells



What are the two subsets of CD4+? - ANSWERSCDw29+

CD45R+



________ positively influence the immune response of T cells and B cells-the helper function. -
ANSWERSCDw29+



_______ induce cytotoxic function in CD8+ cells. - ANSWERSCD45R+



What are the two subsets of CD8+? - ANSWERSCD28+

CD11b+

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