100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Summary Beta Lactam Antibiotics £2.99   Add to cart
Quickly navigate to
Preview
  2.  
  3. Cambridge University (CAM)
  4.  
  5. Microbiology

Summary

Summary Beta Lactam Antibiotics
 4 views  0 purchase

This document explains how bacteria form their cell wall and how beta lactam antibiotics such as penicillin work to kill bacteria by targeting features such as the cell wall. It delves into the chemistry of these antibiotics and their different classes.

Preview 2 out of 9  pages

Document information

  • November 9, 2024
  • 9
  • 2018/2019
  • Summary

Subjects

Written for

All documents for this subject (7)

Seller

avatar-seller
rahadurrahman

Content preview

Beta Lactam Antibiotics

⦁ Bacterial cell walls consist of a mesh-like layer of peptidoglycan (PG) which enables
bacteria to resist intracellular osmotic pressures and build cellular integrity.
Disruption of this cell wall synthesis would be bactericidal where loss in integrity can
lead to cell death by the cell rupture in hypotonic medium explaining the heavy use
of beta lactams.

⦁ PG is a polymer of sugars and amino acids. Peptidoglycan synthesis: (Yao Liu and
Eefjan Breukink, The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic Targets,
Antibiotics 2016, 5, 28) Diagram below

⦁ C55-P- membrane anchor that becomes Lipid I and Lipid II

⦁ MurNAc (NAM): N-acetylmuramic acid

⦁ GlcNAc (NAG): N-acetylglucosamine

⦁ Flippase: transports Lipid II from inner to outer side of membrane where
polymerisation occurs




1

, ⦁ PBP domains:




2

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller rahadurrahman. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £2.99. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

73216 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now

Start selling
£2.99
  • (0)
  Add to cart