Immunology

Asthma- an inflammatory tour on the key players causing inflammation Last document update:   ago

Overall this review will explore the main mechanisms in which inflammation occurs through Th2- high and Th2- low inflammation within different endotypes of asthma. It will explore the controversies which arise in these inflammatory responses and the difficulties and barriers which still faces in understanding these molecular mechanisms. Next it will explore different view with a neuro-immune regulation of inflammation that has come to light in the past couple of years. Finally it will explore di...

The use of checkpoint inhibitors (e.g. pembrolizumab and ipilimumab) has been hailed as a major breakthrough in the treatment of cancer. Discuss why checkpoint inhibitors enhance anti-tumour responses and how they might be improved to be more efficacious Last document update:   ago

Immune checkpoint therapy is a new area of research which is ranked with surgery, chemotherapy radiation to improve survival rates against cancer. The immune checkpoint drug treatments specifically target the regulatory pathways within T cells to enhance anti-tumour responses, a shift from traditional therapies. Over the years there have been many drugs approved for treatments of different cancers, the first being ipilimumab for CTLA-4 blockade and nivolumab and pembrolizumab for PD-1 blockade (...