Lynch syndrome - Study guides, Revision notes & Summaries

Case Study of a Utility of Molecular Testing for a Patient with Suspected Lynch Syndrome.

HBOC correct answers breast, ovarian, prostate, melanoma Familial Adenomatous Polyposis correct answers CHRPE (congenital hypertrophy of the retinal pigment epithelium) Li-Fraumeni correct answers TP53 Early breast, sarcoma (osteo or soft tissue), brain, leukemia, **adrenocortical carcinoma, **choroid plexus carcinoma (childhood), fam hx childhood onset tumors Cowden correct answers Folliular Thyroid, Breast, uterine, macrocephaly, Lhermitte-Duclose disease (LDD)= cerebellar dysplastic...

WGU D027 Practice Test Questions and answers, rated A+. verified. A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of ce...

Women's Health III - Gynecologic Cancers When can genetic counseling be done to test for gynecologic cancers? - correct answer - antenatal - cardiology - cancer - 90% of cancer is sporadic - 10% is hereditary What people are at increased risk of gynecologic cancer? - correct answer - Early age of onset - Multiple affected family members - "Related" cancers in the family (includes pancreatic/prostate) - Multiple primaries - Unusual presentation - Ethnicity = Ashkenazi Jews - Pa...

MB (ASCP) 2022 Already Passed Consider the table below where a child and a possible father (PF) share the listed paternity indices for each locus listed (LOC-A1, LOC-B2, LOC-C3, LOC-D4). Locus Tested PF Child Paternity Index LOC-A1 3 2/3 2.18 LOC-B2 7/5 5 0.798 LOC-C3 15/17 9/17 5.21 LOC-D4 12 12 1.37 Based on the data presented in the table, what is the combined paternity index, CPI, from the loci tested: LOC-A1, LOC-B2, LOC-C3 and LOC-D4? 12.42 9.558 15.56 2.38 12.42 ( CPI is calculated by mu...

An Ames test of a compound suspected to be a mutagen was examined before and after incubation with rat liver extract. Based on the results shown, what do you conclude? correct answersAnswer: Compound is mutagenic without liver enzymes and this activity is further enhanced by liver enzymes. Match the description of each mode of regulation with the illustration diagrammed at the right and record your answer in the order of 1 --> 4. correct answersAnswer: 1. B Ligand-regulated de-repressi...

Hereditary Breast and Ovarian Cancer correct answers BRCA 1/2 Breast 50-87% Second primary tumor 50-64% BRCA 1: 20-45% BRCA 2: 10-30% BRCA 2: Male breast 6-10% Li-Fraumeni Syndrome correct answers -Sarcoma, breast, leukemia, adrenal and many others -May present in almost every way (ie all family members with same cancers or all with different) -Adrenocortical carcinoma considered pathognomonic -50% have some type by 30, 90% by age 60 -TP53 accounts for 70% of individuals Beckwit...

Women's Health- Gynecologic Cancers what are the 2 types of uterine cancer? - correct answer 1. endometrial carcinoma 2. uterine sarcoma- leiomyosarcoma which uterine cancer accounts for 95% of all cases? - correct answer endometrial carcinoma what is endometrial carcinoma? - correct answer cancer of the uterus lining what is uterine sarcoma? - correct answer cancer of the uterine muscle what are risk factors for uterine cancer? - correct answer 1. age- average age is 62 2. ...

Ap Unit 6 Exam Questions Correctly Answered 2024. Scientists conducted a transformation experiment using E. coli bacteria and the pTru plasmid. Samples of the pTru plasmid (lane A) and the chromosomal DNA from two different E. coli strains that the scientists attempted to transform (lane B and lane C) were compared using gel electrophoresis. The results are shown in Figure 1. - CORRECT ANSWER Which of the following statements best explains the experimental results observed in Figure 1 ?...

A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast cancer. d. The x linke...