2023/24 AANP Exam Study Notes || With 100% Correct Solutions

2023/24 AANP Exam Study Notes || With 100% Correct Solutions 2023/24 AANP Exam Study Notes || With 100% Correct Solutions Migranes - ANSWER - - Symptoms: Throbbing pain behind one eye Photophobia, phonophobia, N/V - At-Risk Patients: Adult females - Aggravating Factors: Red wine, MSG, aspartame, menstruation, stress Trigeminal neuralgia - ANSWER - - Symptoms: Type 1: Intense, sharp, shock-like, stabbing pain; Type 2: constant, aching, burning pain - At-Risk Patients: Older adults and elderly - Aggravating Factors: Cold food, cold hair, chewing, talking, touch Cluster HA - ANSWER - - Symptoms: "Icepick" piercing pain behind one eye/temple Tearing, rhinorrhea, ptosis, miosis Homer's syndrome - At-Risk Patients: Middle-aged females - Aggravating Factors: Occurs at same time, daily, in clusters Weeks to months Tension HA - ANSWER - - Symptoms: b/1 "band-like" pain; dull, may last a day; may have spasms of trapezius muscles - At-Risk Patients: Adults - Aggravating Factors: Stress Migrane - ANSWER - - Acute tx: Ice pack, rest, dark room Sumatriptan or Toradol Prochlorperazine for - Prophylaxis/Other: TCA, BBs, Effexor, Topamax {not if hx of kidney stones) Pharmacokinetics - ANSWER - Movement of drugs through body Pharmacodynamics - ANSWER - Physiologic and biochemical effects of drugs Pharmacogenomics - ANSWER - Study of how genes affect response to meds Half-life - ANSWER - Amount of time it takes for drug concentration to decrease 50% First-Pass Effect - ANSWER - Oral drug enters portal circulation - in liver, CYP450 metabolizes drug, then it is released to body; can bypass first-pass effect via IV, gels/creams/patches, buccal When asked about drug interactions, think of these - ANSWER - · Macrolides · Antifungals · Cimetidine · Citalopram · Protease inhibitors · Grapefruit juice (Interacts with statins, erythromycin, CCBs, antivirals, amiodarone, benzos, cisapride, carbamazepine, buspirone) Safety Issues with Common Meds Drug: Thiazolidinediones e.g. pioglitazone