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IMM250 MIDTERM EXAM QUESTIONS AND REVISED ANSWERS NEW UPDATE
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IMM250 MIDTERM EXAM QUESTIONS AND REVISED ANSWERS NEW UPDATE Which of the following is not a property of adaptive immunity A. Tolerance to self-antigens B. Memory C. High specificity D. Improved secondary responses E. Fast response (within 24 hours) - Answer E. Fast respon...

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  • October 21, 2024
  • 44
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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IMM250 MIDTERM EXAM QUESTIONS
AND REVISED ANSWERS NEW
UPDATE

Which of the following is not a property of adaptive immunity

A. Tolerance to self-antigens

B. Memory

C. High specificity

D. Improved secondary responses

E. Fast response (within 24 hours) - Answer ✅ E. Fast response (within 24 hours)

The first antibody isotype expressed by a newly produced B cell in the bone marrow is

A. IgA

B. lgD

C. lgE

D. lgG

E. lgM - Answer ✅ E. lgM

IgE are mostly found attached to Pc receptors on the membrane of

A. All leukocytes

B. Neutrophils

C. Only T and B cells

D. Mast cells

,E. Macrophages - Answer ✅ D. Mast cells

The T cell receptor (TCR) recognizes antigen

A. As a native protein

B. In the form of a surface exposed protein on pathogens

C. As a short peptide

D. On the surface of antigen presenting cells

E. Both C and D - Answer ✅ E. Both C and D

Which of the following is observed in SCID patients

A. Decreased production of antibodies but normal T cell function

B. A partial block in T cell formation

C. A deficit of innate immunity

D. complete block in both T and B cell function

E. All of the above - Answer ✅ D. complete block in both T and B cell function

Which of the following undergo clonal selection following antigen stimulation

A. Neutrophils

B.Mast cells

C. Lymphocyte precursor stem cells

D. B cells

E. C and D are correct - Answer ✅ D. B cells

Which of the following is true about CD4

A. Constitutes the essential and only "signaling" component of TCR

B. Recognizes MHC class II molecules

C. Expressed by 35% of blood T lymphocytes in humans

,D. Is co-expressed with CD8 on peripheral mature T cells

E. Mainly expressed by T cells with cytotoxic activity - Answer ✅ B. Recognizes MHC
class II molecules

Identify the correct statement. The "Royal Experiment" refers to:

A. The famous cowpox experiment performed by the royal physician Edward Jenner on
members of the royal family in London

B. A famous experiment performed by llya Metchnikoff on members of the royal family
in London demonstrating that macrophages are immune cells

C. The decision to "variolate" members of the royal family in London after several
clinical trial on prisoners and orphans

D. The decision to variolate members of the royal family in London to protect them from
the Black Death. - Answer ✅ C. The decision to "variolate" members of the royal family
in London after several clinical trial on prisoners and orphans

The scientist who restored interest in the innate immune system is:

A. Frank MacFarlane Burnet

B. Louis Pasteur

C. Paul Ehrlich

D. Charles Janeway - Answer ✅ D. Charles Janeway

Examples of intrinsic barriers to pathogens in the gut
include

A. Anti-microbial peptides

B. Rapid cell turnover

C. Mucus production

D. Commensal flora

E. All of the above - Answer ✅ E. All of the above

Antimicrobial peptides can be:

A. Secreted by epithelial cells

, B. Found in the gut lumen

C. Found in the granules of neutrophils

D. All of the above - Answer ✅ D. All of the above

What of the following is NOT a characteristic of mucins?

A. Only produced in response to infection

B. Highly glycosylated proteins

C. Form laace structures

D. Protect the mucosal surfaces of gut and respiratory tract - Answer ✅ A. Only
produced in response to infection

Identify the correct statement. Gram negative bacteria:

A. Do not possess peptidoglycan in their cell wall

B. Possess a thick peptidoglycan layer in their cell wall

C. Easily decolorize when treated with ethanol after crystal violet staining

D. Are not recognized by NOD receptors - Answer ✅ C. Easily decolorize when treated
with ethanol after crystal violet staining

Clostridium difficile is:

A. A bacterial agent that may cause infection as a
consequence of antibiotic therapy

B. The bacterial agent responsible for stomach ulcers

C. One of the most common causes of "food poisoning"

D. All of the above - Answer ✅ A. A bacterial agent that may cause infection as a
consequence of antibiotic therapy

An example of a PAMP found only on Gram negative bacteria is:

A. Peptidoglycan

B. CpG Dna

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