Imatinib - Study guides, Class notes & Summaries

Lecture notes for the Cancer Pharmacology section of module LIFE 206 - Drug Action. Provides an overview of: What is cancer, what causes cancer, challenges facing cancer therapy, evaluation of cancer drugs, targeted therapy, protein kinases (example BCR-ABL tyrosine kinase/CML/Imatinib), EGFR tyrosine kinase, and apoptosis pathways. Also includes 50 example exam question/answers.

Bonus Questions on Molecular Diagnostics [100% PASS] /verified/ polymerase slippage *Ans* DNA polymerase can lose its place in a repetitive sequence tract, and either leaves out or add an inappropriate number of repeat units Imatinib *Ans* tyrosine kinase inhibitor (Gleevec) What is the rate of mutation per round of DNA replication? A. 1 in 1,000 base pairs B. 1 in 10,000 base pairs C. 1 in 1,000,000 base pairs D. 1 in 1,000,000,000 base pairs *Ans* D. 1 in 1,000,000,000 base pairs Wh...

What are the 3 phases of chronic myelogenous leukemia (CML)? - 1. Chronic (increase in WBCs or Plts and splenomegaly, "stable phase" lasting 1-4 years) 2. Accelerated phase ( ~ few months) 3. Blast phase (transition to ACUTE leukemia) What is the ONLY CURE for CML? - Allogeneic HSCT (stem cell transplant) When is AHSCT indicated? - Blast crisis accelerated phase unresponsive or intolerant to TKIs What is the purpose of TKIs in treating CML? - To maintain patient in the chronic phase ...

Question 1: A 59-year-old man with a recent history of erectile dysfunction has been assessed and prescribed sildenafil (Viagra). When providing patient education to this man, the nurse should tell him which of the following? Correct Answer Answer: "You might find that your face becomes flushed, or you get a headache after taking Viagra." Correct Answer Question 2: A patient takes etoposide for a testicular tumor refractory treatment. The nursing assessment reveals that he is also taki...

Obstructive Spirometry Results - decreased FEV1/FVC (<70%) - Inc TLC Restrictive Spirometry Results - increased/normal FEV1/FVC - Dec TLC Bullous pemphigoid - prodrome of pruritic rash - followed by tense bullae - no oral mucosa involvement phemigus vulgaris - painful, flaccid blisters - oral mucosa involvement temporal lobe epilepsy - focal seizure with impaired awareness - automatisms (lip smacking) CKD with secondary hyperparathyroidism - low ...

NURS 6521 Adv. Pharmacology Final Exam Questions And Answers (Verified And Updated) Question 1: A 59-year-old man with a recent history of erectile dysfunction has been assessed and prescribed sildenafil (Viagra). When providing patient education to this man, the nurse should tell him which of the following? - answer Answer: "You might find that your face becomes flushed, or you get a headache after taking Viagra." - answer Question 2: A patient takes etoposide for a testicular tumor r...

NURS 6521 Adv. Pharmacology Final Exam Questions and Answers 100% Correct Question 1: A 59-year-old man with a recent history of erectile dysfunction has been assessed and prescribed sildenafil (Viagra). When providing patient education to this man, the nurse should tell him which of the following? - Correct Answer ️️ - Answer: "You might find that your face becomes flushed, or you get a headache after taking Viagra." - Correct Answer ️️ - Question 2: A patient takes etoposide f...

A patient is receiving carboplatin. The nurse would expect to administer this drug by which route? - Intravenous The nurse may be asked to administer which medications to a client to counteract the increase in uric acid and subsequent hyperuricemia resulting from the metabolic waste buildup from rapid tumor lysis? - allopurinol A nurse should understand which adverse effects of antineoplastic drugs are related to the death of rapidly growing cells? (Select all that apply.) - *Alopecia *Le...

NURS 6521 Adv. Pharmacology Final Exam With Correct Questions and Answers Updated For Excellence_100% A+_ Walden University Question 1: A 59-year-old man with a recent history of erectile dysfunction has been assessed and prescribed sildenafil (Viagra). When providing patient education to this man, the nurse should tell him which of the following? Answer: "You might find that your face becomes flushed, or you get a headache after taking Viagra." Question 2: A patient takes etoposide...

NURS 6521 Adv. Pharmacology Final Exam Questions and Answers Question 1: A 59-year-old man with a recent history of erectile dysfunction has been assessed and prescribed sildenafil (Viagra). When providing patient education to this man, the nurse should tell him which of the following? -Answer- Answer: "You might find that your face becomes flushed, or you get a headache after taking Viagra." -Answer- Question 2: A patient takes etoposide for a testicular tumor refractory treatment. The...