Gpcr - Study guides, Class notes & Summaries

Molecular Drug Targets - ANSWER-Receptors-45% Enzymes-28% Hormones-11% Unknown-7% Ion Channels-5% DNA-4% Channel-Linked (Ionotropic) Receptors - ANSWER-Produce cellular effects in milliseconds Nicotinic ACh receptor GPCRs - ANSWER-Effects happen in seconds Muscarinic ACh receptor Kinase-linked receptors - ANSWER-Effects happen in minutes Insulin receptor Receptors linked to gene transcription - ANSWER-Effects happen in hours Estrogen receptor Heterotrimeric G proteins - A...

This document consists of a summary of the course Drug Target Biochemistry and Signaling, corresponding to the Master Drug Discovery Sciences.

Question 1 2.5 / 2.5 pts Indicate whether each of the following descriptions better applies to COPI- (1), COPII- (2), or clathrin- (3) coated vesicles. Your answer would be a four-digit number composed of digits 1 to 3 only, e.g. 1322. ( ) They mediate transport from the ER to the cis Golgi network. ( ) Their coat protein forms a three-legged structure called a triskelion. ( ) They are pinched off from their donor compartment by a dynamin collar. ( ) They are involved in retrograde trans...

BERNE AND LEVY PHYSIOLOGY 7 TH EDITION KOEPPEN ALL CHAPTERS(01-44) Chapter 01: Principles of Cell FunctionTest Bank Multiple Choice 1. The subcellular structure that degrades proteins is called the: A. Tight junction B. Mitochondria C. Lysosome D. Plasma membrane E. Ribosome ANS: C 2. An experiment is done to measure the uptake of an amino acid into a cell. The following data are obtained: If Na+ is removed from the extracellular bathing solution, or if a drug is added that...

Made this summary for DRUG TARGETS BIOCHEMISTRY AND SIGNALING. Summary is detailed and complete. However, chapter 11 and 12 were not saved correctly. These are lost. I had a printed backup which is scanned and included in this summary. The quality is the same as the rest of the summary. The only thing is that it is scanned and 2 on 1 side (still readable).

Why is celecoxib selective for COX-2 inhibition as compared to COX-1 inhibition? COX-1 contains Ile-523, whereas COX-2 contains Val-523, which permits celecoxib binding. COX-1 contains Ile-523, whereas COX-2 contains Val-523, which blocks celecoxib binding. COX-1 contains Val-523, whereas COX-2 contains Ile-523, which permits celecoxib binding. COX-1 contains Val-523, whereas COX-2 contains Ile-523, which blocks celecoxib binding. COX-2 is located in the endoplasmic reticulum where ...

2 ways phosphate addition/removal causes conformational changes - Answer 1)Phosphorylation has a lot of negative charges that interfere with interactions between substrates --> forces protein into different conformations 2) phosphorylation of an enzyme can also alter substrate-binding affinity via electrostatic repulsion what happens to the GPCR and g-protein when a hormone reaches the GPCR receptor on cell membrane? - Answer hormone triggers a conformational change in receptor, which s...

Week 6 UNE Medical Biochemistry Review Exam Questions With 100% Correct Answers Glycogen is stored primarily in the: - answerliver and skeletal muscles Pathway for synthesis and degradation are identical. True or False - answerTrue Enzymes used for Glycogen synthesis - answerPhosphoglucomutase, UDPGlc pyrophosphorylase, and Glycogen synthase Glycogen synthesis - UDPGlc pyrophosphorylase: - answerGlucose 1-P + UTP → UDPGlc Glycogen synthesis - Phosphoglucomutase - answerGlucose 6-P is i...

Week 6 UNE Medical Biochemistry Review Exam Questions With 100% Correct Answers Glycogen is stored primarily in the: - answerliver and skeletal muscles Pathway for synthesis and degradation are identical. True or False - answerTrue Enzymes used for Glycogen synthesis - answerPhosphoglucomutase, UDPGlc pyrophosphorylase, and Glycogen synthase Glycogen synthesis - UDPGlc pyrophosphorylase: - answerGlucose 1-P + UTP → UDPGlc Glycogen synthesis - Phosphoglucomutase - answerGlucose 6-P is i...

G-Protien coupled receptors and how they interact with drugs - G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can stimulate t...