Nplex 2 pharm Study guides, Class notes & Summaries

Acyclovir - ANTIVIRAL (Inhibits DNA polymerase) IND: - HSV ixn and prevention, VZV, EBV, disseminated neonatal herpes, CMV ixn ACT: - Nucleoside analog inhibiting viral replication, NON-CURATIVE A/E: - HA, diarrhea, nausea, delirium, tremor, Htn, transent renal dysfunction w/ high doses, encephalopathy (IV), CAN PROMOTE EMERGENCE OF RESISTANT STRAINS C/I: - Preg C INT: - Synergistic toxicity w/ ZIDOVUDINE (AZT). MONITOR: urinalysis, BUN, serum creatinine, LV enz, CBC Rx: Oral, topic...

NPLEX 2 Pharmacology Full (Elective and Core) Study Guide (Latest Update 2025)

5-fluorouracil -:- ANTI-NEOPLASTIC/ ANTI-METABOLITE IND: - Carcinoma of the breast, colon, head and neck, pancreas, rectum or stomach - TOPICAL for management of actinic (solar) keratosis, superficial basal cell carcinomas ACT: - Pyrimidine antimetabolite, blocks methylation of deoxyuridylic acid and interferes with DNA synthesis - Stops thymidilate synthase. A/E: - Dermatitis, vomiting, diarrhea, alopecia, heartburn, nausea, anorexia, stomatitis, esophagitis, leukopeni...