NSG 533 (NSG533)
Wilkes University
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NSG 533 / NSG533 ADVANCED PATHOPHYSIOLOGY AND PHARMACOLOGY COVERING EXAMS 1,2,3, AND 4. QUESTIONS WITH 100% VERIFIED ANSWERS. LATEST 2024/2025
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This package consists of exams 1 to 4 which covers both advanced pharmacology and advanced pathophysiology. All
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NSG 533 ADVANCED PATHOPHYSIOLOGY EXAM 4. QUESTIONS WITH 100% CORRECT ANSWERS.
- Exam (elaborations) • 56 pages • 2025
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COPD and the alveolar capillary membrane 
in COPD, alveoli is damaged, which can destroy pulmonary capillary --> loss of surface area for gas exchange --> hypoxia 
 
 
fibrotic lung disorders and the alveolar capillary membrane 
scarring/thickening of the lung tissue --> lungs do not expand well --> dyspnea 
 
 
two factors that affect blood flow through the pulmonary vasculature 
1. vasoconstriction 
2. decreased cardiac output 
 
 
etiology/risk factors of pneumonia 
RESTRICTIVE 
-...
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NSG 533 / NSG533 ADVANCED PATHOPHYSIOLOGY EXAM 4. QUESTIONS WITH 100% VERIFIED ANSWERS.
- Exam (elaborations) • 21 pages • 2025
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Progressive Stage of Shock 
Compensatory mechanisms are failing, anaerobic metabolism fails to maintain energy needs. Profound vasodilation from SNS failure results in ischemia, increasing lactic acid, metabolic acidosis, increased capillary pressure/interstitial edema, altered cellular functioning and cell membrane permeability (lysosomes released and auto-digest cells). 
 
 
Refractory Stage of Shock 
Irreversible changes in organ function, may patients won't survive. Tissue perfusion worse...
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NSG 533 / NSG533 ADVANCED PHARMACOLOGY EXAM 4. QUESTIONS WITH 100% CORRECT ANSWERS.
- Exam (elaborations) • 42 pages • 2025
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MODS: mortality 
The mortality rate increases with increased number of organ dysfunctions 
20% mortality rate if there is 1 organ dysfunction 
40-45% mortality rate if there are 2 organs dysfunctions 
68-70% mortality rate if there are 3 organ dysfunctions 
80-85% mortality rate if there are 4 organ dysfunctions 
Sepsis: patho -Clinical manifestations of shock are persistent low arterial pressure, low tissue 
perfusion, low SVR from vasodilation, and alteration in oxygen extraction by all...
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NSG 533 / NSG533 ADVANCED PHARMACOLOGY EXAM 3. QUESTIONS WITH 100% CORRECT ANSWERS.
- Exam (elaborations) • 32 pages • 2025
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calculate cariac output 
heart rate x stroke volume 
 
 
factors that determine cardiac output 
 
 
 
what is preload? 
 
 
 
two factors that determine preload: 
 
 
 
two factors that impact end systolic volume 
 
 
 
what is afterload? 
 
 
 
three factors that impact myocardial contractility: 
 
 
what is an inotrope? 
 
 
positive inotropic agents 
 
 
 
Negative inotropic agents 
 
 
 
what's an artery 
 
 
what's a vein 
 
 
 
vascular compliance 
 
 
calculate BP 
 
 
systolic bloo...
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NSG 533 ADVANCED PATHOPHYSIOLOGY EXAM 3. QUESTIONS AND ANSWERS.
- Exam (elaborations) • 25 pages • 2025
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Adipocytes vs Adipokines 
Cytes: cells; stores triglycerides 
Kines: hormones; control food intake, energy expenditures, lipid storage, insulin sensitivity, etc 
 
Obesogens 
-Chemicals that stimulate fat development and disrupt hormone signals 
-Can cross placenta and in breast milk, passed down in generations 
 
 
Obesogens exposure routes and examples 
Placenta, breast milk, intake, pollutants 
-phytoestrogens 
-pesticides 
-plastics 
-cleaners 
 
Leptin 
-Hormone that inhibits appetite and p...
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NSG 533 ADVANCED PHARMACOLOGY EXAM 3. QUESTIONS WITH 100% CORRECT ANSWERS.
- Exam (elaborations) • 34 pages • 2025
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Tx for bipolar 
-Lithium ("A") was the first medication approved for treatment of bipolar mania and depression. It reduces the incidence of recurrence of mania, hypomania, and depression by about two-thirds. Lithium has a significant anti-suicide effect with an estimated eight- to ninefold reduction in risk. It is dosed at nighttime or twice daily. Lithium has a narrow therapeutic window, and there are numerous drug-drug interactions (including serotonergic drugs). 
-Both olanzapine (Zypre...
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NSG 533 ADVANCED PHARMACOLOGY EXAM 3. QUESTIONS WITH 100% VERIFIED ANSWERS.
- Exam (elaborations) • 21 pages • 2025
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List sources of lead in the environment 
Water, artificial turf, imported candy, alternative medicines and herbal remedies, sindoor, old and imported toys, and occupational hazards. 
 
 
What are the hematological, renal, and skeletal effects of plumbism in children? 
-Anemia, 
-damaged proximal tubules and loop of Henle, 
-interstitial nephritis, 
-nephrotoxicity, 
-decreased metabolism of Vit D (and therefore calcium), 
-slows the growth of long bones and overall decreased growth rate. 
 ...
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NSG 533 ADVANCED PHARMACOLOGY EXAM 3. QUESTIONS WITH 100% CORRECT ANSWERS.
- Exam (elaborations) • 11 pages • 2025
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How to take bile acid sequestrants 
 
 
 
Bempedoic Acid can increase 
 
 
 
Lipid lowering agents that are safe in pregnancy 
 
 
 
Most effective triglyceride lowering drugs 
 
 
 
PCSK9 inhibitors 
 
 
 
APTT range for heparin therapy 
 
 
Warfain inhibits which clotting factors? 
 
 
 
INR value for warfarin 
 
 
 
Why is warfarin initiated with a fast acting heparin? 
 
 
 
Direct thrombin inhibitors 
 
 
 
NOACs
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NSG 533 / NSG533 EXAM 1. QUESTIONS WITH 100% CORRECT ANSWERS.
- Exam (elaborations) • 21 pages • 2025
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Complete dissolution of the chromatin of a dying cell due to enzymatic degradation by endonucleases. 
Karyolysis 
-these 3 changes (Pyknosis, karyorrhexis, and karyolysis lead to destruction of the nucleus- which will eventually cause the cell to die) 
 
Discuss the relationship of apoptosis to AIDS 
HIV indirectly triggers programmed cell death/apoptosis that contributes to the decline in CD4 T lymphocyte counts throughout the course of HIV infection. The HIV induced; premature destruction of l...
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