Cyp2d6 - Study guides, Class notes & Summaries

Sertraline (Zoloft) Major Side Effects Answer insomnia, somnolence, HA, dry mouth, sex dysfunction, nausea & diarrhea Fluoxetine (Prozac) Major Side Effect Answer Activating (UPPER); AGITATION, INSOMNIA, nausea, vomiting, sex dysfunction, GI, serotonin syndrome Paraoxetine (Paxil) Major Side Effects Answer Anticholinergic (can't see, can't sleep, can't shit, can't spit), CYP2D6 inhibitor, increases TCA, phenothiazines, Type 1C antiarrhythmics, weight gain, GI, sex dysfuncti...

GMS 6510 PS7 Questions and Answers 100% Solved roughly what fraction of lung cancer cases could be prevented with the absence of smoking? -1/4 -1/6 -1/2 -6/8 -7/8 7/8 what functional group is formed on BaP that ultimately causes adduct formation? - ketone -alcohol -ester -nitrosamine -epoxide epoxide what enzyme is responsible for activating PAHs? -CYP2E1 -CYP1A1 -CYP1A2 -GSTM1 -CYP2D6 CYP1A1 in tobacco-associated COPD, is the ability of the body to respond to reactive oxygen...

Addiction Medicine Exam CSAM Cyproheptadine - CORRECT ANSWER-5-HT2A receptor antagonist Serotonin syndrome - CORRECT ANSWER-Caused by excessive stimulation of 5-HT2A receptors and possibly 5-HT1A receptors In patients withdrawing from both hypnotic - sedatives and CNS stimulants, which is treated first? - CORRECT ANSWER-hypnotic - sedatives For those patients on both opiates and sedative-hypnotics, which should be tapered first? - CORRECT ANSWER-Taper the sedative-hypnotic first while ke...

A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast cancer d. The x-linked O...

Pharmacology Ch. 31 Opioid Analgesics & Antagonistswhat are the major therapeutic uses of opioid drugs? - correct answer analgesics antitussives antidiarrheal what are partial opioid agonists? what is the prototype of a strong analgesic or full agonist? - correct answer -partials exert less analgesia than morphine -morphine is the prototype which drugs undergo extensive 1st pass metabolism? - correct answer morphine hydromorphone oxymorphone what is an opiate? - correct answer drug deriv...

CYP2D6 - CORRECT ANSWER Need to increase doses of SSRI, beta blockers etc. Codeine can be deadly CYP2C9 - CORRECT ANSWER Decrease warfarin dose Test for gene VCORC1 mutation CYP3A4 - CORRECT ANSWER Decreases elimination Increase toxicity of Amio Schedule I - CORRECT ANSWER no accepted medical use in the US it may not be prescribed. heroin,various opium derivatives,hallucinogenic substances Schedule II - CORRECT ANSWER No refills, no telephone order...

A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast cancer. d. The x linked...

Cocaine sympathomimetics (stimulant) intranasal (50 min) Metabolized by: butyrylcholinesterase Metabolite: benzoylecgonine Inhibits (blocking) the reuptake: Dopamine, norepinephrine, serotonin Sympathomimetics (stimulant) Replacement or substitution therapy Bruxism, gum disease, cardiovascular effects Cocaine is primary taken? intranasal Cocaine's half-life 50 min Cocaine is metabolized by butyrlcholinesterase Metabolite: benzoylecgonine Cocaine's mechanism of action inhibits (block...

Which CYP-interacting drugs increase the levels of propranolol and metoprolol? correct answers CYP2D6 inhibitors (e.g. amiodarone, paroxetine) How does digoxin benefit CHF? Atrial fibrillation? correct answers Digoxin is a mild positive ionotrope to help HF and is a negative chronotrope to help Afib. Which beta-blocker is more likely to cause CNS side effects, such as depression and insomnia? Why correct answers Propranolol will have more CNS side effects due to its greater lipid solubilit...

G-Protien coupled receptors and how they interact with drugs Correct Answer G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can st...