Camptothecin - Study guides, Class notes & Summaries

1. A nurse is presenting information at a health fair concerning cancer. When questioned about the use of green tea, the nurse would point out which potential effect of green tea? A) Dental caries B) Damage to heart C) Insomnia D) Damage to liver Answer: C Rationale: The nurse should inform the client that green tea can cause insomnia, nervousness, restlessness, and GI upset because it contains caffeine. Green tea is known to improve dental health and maintain health of the heart and l...

1. A nurse is presenting information at a health fair concerning cancer. When questioned about the use of green tea, the nurse would point out which potential effect of green tea? A) Dental caries B) Damage to heart C) Insomnia D) Damage to liver Answer: C Rationale: The nurse should inform the client that green tea can cause insomnia, nervousness, restlessness, and GI upset because it contains caffeine. Green tea is known to improve dental health and maintain health of the heart and l...

Introductory Clinical Pharmacology 12th Edition by Susan M Ford 1. A nurse is presenting information at a health fair concerning cancer. When questioned about the use of green tea, the nurse would point out which potential effect of green tea? a. Dental caries b. Damage to heart c. Insomnia d. Damage to liver Answer: C Rationale: The nurse should inform the client that green tea can cause insomnia, nervousness, restlessness, and GI upset because it contains caffeine. Green tea is ...

OCN PRACTICE QUESTIONS #1 WITH COMPLETE SOLUTIONS 100% Which of the following is not routinely included as part of a diagnostic work-up for colorectal cancer? a. barium enema b. colonoscopy c. bone marrow biopsy d. carcinoembryonic antigen (CEA) - correct answer c. bone marrow biopsy A bone marrow biopsy is not routinely performed as part of a diagnostic work-up for colorectal cancer. Barium enemas provide a clear picture of the large intestine and are useful in detection of smaller tumo...

PMCOL 344 Cancer Exam Latest Update ...

ONS Chemotherapy Administration What do alkylating chemotherapy drugs do? - ANS Chemotherapy drugs that are cell cycle nonspecific, so they exert their effects in all phases of the cell cycle. They directly damage DNA to prevent cancer cells from reproducing. They cause breaks in the DNA or cross-linking in a process called alkylation, which causes the drug to interfere with DNA replication. neoadjuvant therapy - ANS a cancer treatment that precedes other primary tr...

PMCOL 344 Cancer Exam Study Guide. Nucleobases - answerPurine analogs that are converted into fake nucleotides that get incorporated into DNA and inhibit various enzymes. Camptothecin - answerTopoisomerase 1B inhibitor that forms a stable tertiary complex with TI-DNA complex. Causes DNA strand breaks that result in apoptosis. However, low blood solubility. Irinotecan - answerSemisynthetic analogue of camptothecin to improve solubility while retaining cytotoxicity. Topoisomerase 1B inhibit...

©THEBRIGHTSTARS 2024 PMCOL 344 - Topoisomerase inhibitors. Exam Questions With Correct Answers Examples of DNA "cutters" topoisomerases inhibitors - answer* camptothecin and derivatives * anthracyclines * podophyllotoxin derivatives many topoisomerase inhibitors are - answerprodrugs DNA topoisomerases are important in - answerDNA replication and RNA transcription type I topoisomerases - answerchange the degree of supercoiling of DNA by causing aa breaks and re-ligation (subtypes IA-...

Fundamentals Of Chemotherapy Immunotherapy Administration – Test Questions And Correct Answers – Best Scored!! 2023 Hematologic cancer (blood cancer) - Correct Answer--cancer that begins in bone marrow or immune system cells. -Ex: leukemia, lymphoma, multiple myeloma Leukemia - Correct Answer-cancer starts in blood-forming tissues like bone marrow -causes lots of abnormal blood cells to be produced and enter bloodstream Lymphoma - Correct Answer--cancer that begins in immune system ...

Alkylating Agents MOA -Inactive until metabolized by the microsomal P450 system -Metabolism forms highly reactive electrophils that react with neutrophiic groups cross-linking DNA and interfering with its function Classical = carmustine, cyclophosphamide, mechlorethamine Non-Classical = procarbazine, dacarbazine, temazolamide, bendamustine Cyclophosphamide -Classical alkylating agent Toxicity - bone marrow suppression (days 8-14), cystitis, cardiac toxicity (high doses), immunosupp...