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PEBC Questions And Answers| 296 questions| With Complete Solutions
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Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs) correct answer: Half-life (T1/2) Inducers of Cytochrome P450 (CYP450) (4) correct answer: Barbiturates Phenytoin Carbamazepine Rifampin Inhibitors of CYP450 correct answer:...

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  • June 6, 2023
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  • 2022/2023
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PEBC Questions And Answers| 296 questions|
With Complete Solutions
Time it takes for amount of drug to fall to half of its value,
constant in first order kinetics (majority of drugs) correct
answer: Half-life (T1/2)

Inducers of Cytochrome P450 (CYP450) (4) correct answer:
Barbiturates
Phenytoin
Carbamazepine
Rifampin

Inhibitors of CYP450 correct answer: Cimetidine
Ketoconazole
Erythromycin
Isoniazid
Grapefruit

Their MOA utilizes intracellular receptors: correct answer:
Thyroid and steroid hormones

This compound's MOA utilizes transmembrane receptors:
correct answer: Insulin

Antidote used for organophosphate/anticholinesterase correct
answer: Atropine, pralidoxime (2-PAM)

Antidote used for acetaminophen (APAP) toxicity correct
answer: N-acetylcysteine

,Antidote used for heparin toxicity correct answer: Protamine
Sulfate

Antidote used for warfarin toxicity correct answer: Vitamin K
and Fresh frozen plasma (FFP)

Antidote for tissue plasminogen activator (t-PA), streptokinase
correct answer: Aminocaproic acid

Antidote used for opioid toxicity correct answer: Naloxone
(IV), naltrexone (PO)

Antidote used for benzodiazepine toxicity correct answer:
Flumazenil

Interaction with this drug requires dose reduction of 6-MP(6-
mercaptopurine) correct answer: Allopurinol

May protect against doxorubicin cardio-toxicity by chelating
iron correct answer: Dexrazoxane

Blows DNA (breaks DNA strands), limiting SE is pulmonary
fibrosis correct answer: Bleomycin

Binds tubulin and prevents the disassembly of microtubules
during the M phase of the cell cycle inducing mitotic arrest
correct answer: Paclitaxel (taxol)

Anti-estrogen used for estrogen receptor + breast cancer correct
answer: Tamoxifen

,Anti-emetics used in association with anti-cancer drugs that are
5-HT3 (serotonin receptor subtype ) antagonist correct answer:
Odansetron
Granisetron
Dolasetron
Palonosetron

Hormone inhibiting prolactin release correct answer: Dopamine

ACTH analog used for diagnosis of patients with corticosteroid
abnormality correct answer: Cosyntropin

Synthetic analog of ADH hormone used for diabetes insipidus
and nocturnal enuresis correct answer: Desmopressin (DDAVP)

Most widely used thyroid drugs such as Synthroid and Levoxyl
contain correct answer: L-thyroxine (T4)

Thioamide less likely to cross placenta, inhibits peripheral
conversion of T4 to T3 in high doses, and should be used with
extreme caution in pregnancy correct answer: PTU

PTU (propylthiouracil) MOA correct answer: Inhibits thyroid
hormone synthesis by blocking iodination of the tyrosine
residues of thyroglobulin

Some side effects of corticosteroids correct answer:
Hyperglycemia
Osteopenia
Impaired wound healing

, inc. risk of infection
inc. appetitie
HTN
Edema
PUD
Euphoria
Psychosis

Diuretic used to antagonize aldosterone receptors correct
answer: Spironolactone

Common SE of spironolactone correct answer: Gynecomastia
and hyperkalemia

Selective estrogen receptor modulator (SERM) used for
prevention of osteoporosis and currently being tested for
treatment of breast cancer (Stars study) correct answer:
Raloxifene

Non-steroidal estrogen agonist causes clear cell adenocarcinoma
of the vagina in daughters of women who used it during
pregnancy correct answer: Diethylstillbestrol (DES)

Converted to more active form DHT by 5 alpha-reductase
correct answer: Testosterone

Product of proinsulin cleavage used to assess insulin production
correct answer: C-peptide

Long acting insulin correct answer: Ultralente (humulin U)

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