Gene silencing - Study guides, Class notes & Summaries

Test Bank for Biochemistry 2e 2nd Edition by Roger L Miesfeld, Megan M McEvoy. Complete Chapters (Chap 1 to 23) test bank are included with answers. PART 1 Principles of Biochemistry 1 Principles of Biochemistry 2 Physical Biochemistry: Energy Conversion, Water, and Membranes 3 Nucleic Acid Structure and Function PART 2 Protein Biochemistry 4 Protein Structure 5 Methods in Protein Biochemistry 6 Protein Function 7 Enzyme Mechanisms 8 Cell Sig...

UNT Biology 1710 Practice Exam 3|52 Questions with Verified Answers An excellent example of the genetic phenomenon known as continuous variation would be: a. flower color in plants. b. height in humans. c. human blood groups. d. epistasis. e. fur color in arctic animals - CORRECT ANSWER B) height in humans A human genetic trait passed from one generation to the next has an unusual inheritance pattern. The genotype and phenotype of the offspring depends only upon the genotype of the mo...

When does RNA-mediated gene silencing occur? correct answers After transcription of an mRNA but before translation What is gene silencing? correct answers When RNA interferes and prevents protein synthesis through base pairing between ncRNA and mRNA. What is NOT part of translational termination? correct answers Uncharged tRNA recognition of stop codon in the mRNA Which type of interaction is NOT a functional mechanism by which IncRNA regulates gene expression? correct answers IncRNA ca...

Core Promoter Elements ~~> TATA box = repetitive sequence of thymine and adenine Initiator (INR) = sequence of pyramidines like thymine and cytosine DPE = downstream promoter elements found along the DNA Common to have >1 promoter but not all of them CpG islands ~~> Sequences high in CG frequency. They are able to escape methylation which would lead to gene silencing. Demethylation would lead to over expression of genes. Regulatory Promoter Elements ~~> UAS and URS f...

Exam 1 LMR questions and answers Draw out medically important bacteria Lac operon sequence lacl, codes for repressor, C-P-O, ZYA Example of a isoform tropomyosin, an actin filament binding protein 3 functions of RNAi naturally in body proliferation, differnetiation, apoptosis What is miRNA double stranded RNA with guide sequence, binds to mRNA and RISC to form RISC complex to degrade mRNA for gene regulation What is RISC RNA induced sil...

Week 3 Quiz #1 is C. 1. Volume neurotransmission refers to? The diffusion of neurotransmitter to nearby neurons. 2. Retrograde neurotransmissions refers to? The flow of neurotransmitter from postsynaptic neuron to presynaptic neuron 3. Use the following CYP450 table to hypothesize drug interactions and their clinical significance for a patient on clozapine who carbamazepine, a mood stabilizer? Clozapine levels would decrease, placing the patient at risk for re-emergence of psychotic sym...

The inheritance of defective genes at birth that are necessary for proper immune system function is an example of a _______________ Immunodeficiency. a. Acquired b. Congenital c. Macrophage d. CD4+T cell 2. In phase 3 of an HIV infection what is most likely to occur: a. Billions of CD4+ T cells are infected b. Persistent swollen lymph nodes c. Persistent yeast infections, fever, diarrhea, and shingles Amount of CD4+ T cells is very low 3. O condition can integrated HIV provirus be removed fro...

Describe the phylogeny of GRs? - ️️Bees. Only about 350 to 400 ORs. Ants have the record for ORs. Unlike honey bees, actually expansion in GRs (also true of Nasonia). Bees lost this shit, down to like 12. Basic pathway of RNAi - ️️1. double stranded RNA is recognized by an enzyme, dicer and cleaved into short piece abotu 21 bp long 2. These 21 bp long sections are recognized by a complex of proteins called RISC (RNA induced silencing complex) which uses them to recognize perfectly m...

What is Methylation? Ans: addition of methyl groups (CH3) to specific DNA nucleotides What performs methylation? Ans: DNA methyltransferases, add primarily to Cytosine bases What bases are primarily methylated? Ans: Cytosine - located in CpG dinucleotides What is a CpG dinucleotide? Ans: side by side Cytosine and Guanine nucleotides in same DNA strand What part of DNA is mostly methylated? Ans: In eukaryotic genomes, most methylated DNA is found in transposable elements and non-coding...

Draw out medically important bacteria Lac operon sequence lacl, codes for repressor, C-P-O, ZYA Example of a isoform tropomyosin, an actin filament binding protein 3 functions of RNAi naturally in body proliferation, differnetiation, apoptosis What is miRNA double stranded RNA with guide sequence, binds to mRNA and RISC to form RISC complex to degrade mRNA for gene regulation What is RISC RNA induced silencing complex Artifcial RNAi siRNA- short infererence RNAs Explain mRNA editin...