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Lecture notes

Lecture notes regulating the transcriptome
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Detailed lecture notes from module, regulating the transcriptome from week 3, lecture 3-5. Content covered included repression of transcriptome.

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  • December 7, 2021
  • 1
  • 2021/2022
  • Lecture notes
  • Mark p
  • 3-5

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Week 3 – transcription repression
Learning outcomes:
- Explain how transcriptional repressors inhibit transcription, and how effectors
influence DNA binding
- Discuss the importance of auxiliary operators, DNA looping and multimerization of
repressors in repression


Cl is class II activation – auto regulates
Effect of repressor concentration on operator occupancy and activity of Pr and Prm:
- Pr conc. increase Or1 has full occupancy and activity of Pr decreases = RNAP cannot
bind by inclusion
- Occupancy at Or2 affects the ability of RNAP to bind to Pr promoter
- As Or2 gets occupied, Prm is activated as it is a weak promoter by cl binding at Or2
- Pr constitutive expressed
- Or3 occupied – reduced conc. of Prm
- Or1 and Or2 have different intrinsic affinities for cl – filled simultaneously –
COOPERATION

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