100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Summary Adrenal physiology and common pathologies £6.49
Add to cart
Quickly navigate to
Preview
  2.  
  3. The University Of Sheffield (TUOS)
  4.  
  5. The University Of Sheffield
  6.  
  7. Medicine Finals

Summary

Summary Adrenal physiology and common pathologies
 9 views  0 purchase

Discusses in detail adrenal physiology, then discusses common conditions that arise due to adrenal gland pathology. Talks about clinical features, investigations and management.

Preview 2 out of 11  pages

Document information

  • December 31, 2021
  • 11
  • 2021/2022
  • Summary

Subjects

Written for

All documents for this subject (10)

Seller

avatar-seller
kathandesai

Content preview

⚫
Adrenals

Adrenal glands are located above kidney

Supplied by suprarenal arteries

Left and right

inferior, superior and middle

Drained differently based on side:

left adrenal vein> renal vein > inferior vena
cava (organs on left have longer course as
they have to cross over to the vena cava
found on the right side of the body.)

right adrenal vein > inferior vena cava




Cortex and medulla:


Medulla:

secretes adrenaline and noradrenaline

sympathetic nervous system control -
sympathetic nervous system activation
releases ACh at synapse, which causes
adrenal medulla to release adrenaline and
noradrenaline

Cortex: produces three different hormones

Mineralocorticoids (aldosterone) —> Zona
glomerulosa G




Adrenals 1

, Made from cholesterol, ACTH activates
enzyme needed in first step

Glucocorticoids (cortisol) —> Zona
fasciculata F

Uses precursors from Zona glomerulosa to
make Glucocorticoids

Androgens (testosterone) —> Zona
reticularis R

Uses precursors from Zona fasciculata to
make androgens

Adrenal cortex

1. Mineralocorticoids (aldosterone)

Affects kidney function, and its release is controlled
by the Renin-angiotensin-aldosterone (RAA)

Increases Na/Water resorption

Promotes K/H excretion



2. Androgens (testosterone and DHEA)

Small contribution to androgen production in males
(due to testes)

produces ~50% of androgens for females

Relevant in congenital adrenal hyperplasia where there
is an over/underproduction —> abnormal sex
development



3. Glucocorticoids (cortisol)

Cortisol is a major glucocorticoid that binds to
intracellular receptors

Exerts affect by activating/supressing gene
transcription

Production is stimulated by ACTH




Adrenals 2

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller kathandesai. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £6.49. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

56326 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now

Start selling
£6.49
  • (0)
Add to cart
Added