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Presentation Biochemistry Symposia (6102BCBMOL)

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The final presentation, including script and references. The aim of this coursework is to present one or two primary papers linked to a specific topic, we chose wound healing and discussed a paper on microRNAs and their role within wound healing.

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  • February 6, 2022
  • 2
  • 2020/2021
  • Presentation
  • Unknown

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Micro RNA and Wound Healing

INTODUCTION RESULTS
Micro RNA’s (miRNA) are small non-coding proteins  Dynamic miRNome changes during the
about 22-nt long. Their functions are based around the inflammatory phase of human skin wound healing.
degradation of mRNA and post-translational gene  miR-132 expression is induced by TGF-β in
modifications. Here Li, et al analyse the role of miRNA keratinocytes.
within wound healing.  Characterization of the transcriptome regulated by
During the inflammatory phase of wound healing miR-132 in keratinocytes.
epidermal keratinocytes induce the release of  miR-132 suppresses keratinocyte chemokine
production by regulating the NF-κB pathway.
inflammatory cytokines such as CXC chemokine ligand 1
 miR-132 promotes keratinocyte growth by
(CXCL1) and IL-8.
regulating STAT3 and ERK pathways.
miRNA-132 has been shown to be a major molecular  HB-EGF is targeted by miR-132 in keratinocytes.
regulator in human keratinocytes with a crucial role in  Lack of miR-132 delays skin wound healing in vivo.
facilitating the shift from the inflammatory phase to the  Inhibition of miR-132 delays reepithelialisation of
proliferation phase. human ex vivo skin wounds.




CONCLU
miRNA-1
healing c
growth f
driving fa
in increa
colleagu
overexpr

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