Lecture notes
T cell activation
- Module
- Immunology
- Institution
- Bournemouth University Talbot Campus (BUTC)
Detailed lecture notes on T cells and their activation processes
[Show more]
Seller
Follow
Content preview
Lecture 10 – T Cell ActivationSimilarities Between BCR and TCR
Multimeric (made up of more than 1 protein). Can be membrane bound (always for TCR).
Polymorphic.
Lacks direct signalling capacity.
Compromise’s immunoglobulin folds.
Unique to every cell.
Differences Between BCR and TCR
BCR is bivalent, TCR is monovalent.
TCR is membrane bound (no effector function).
TCR only has 2 chains not 4.
BCR undergoes class switching and somatic hypermutation. TCR is fixed when it’s made.
BCR binds the whole antigen, TCR binds peptides in association with MHC.
Structure of TCR
- 2 Chains- normally named alpha and beta.
- Each chain is comprised of 2 immunoglobulin domains.
- The short cytoplasmic tail cannot signal.
- The variable region binds to antigen fragments.
CD3= T cell co-receptor.
CD19= marker of B cells.
TCR/BCR signals through co-receptors.
Extensive Variability in TCR
- Extensive polymorphism throughout the genes that encode for TCR. TCR is also generated by
genetic recombination.
- Alpha genes are encoded by VJ and C genes.
- Beta genes are encoded by VDJ and C genes.
- Occurs in the thymus.
T Cells express CD4 [CD4+ T cells] or CD8 [CD8+ T cells].
Genetic recombination= exchange of genetic material between different organisms. This gives
offspring that has a combination of traits different to the parents.
T Cell Antigen Recognition
Responds to short fragments of an antigen presented with major histocompatibility complex
(MHC).
MHC complex with peptide presented upon the surface of other bodily cells.
TCR binds MHC and peptides.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller biomedicalscience4. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £7.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75632 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now