Lecture notes
The microbiome
- Module
- Medicine
- Institution
- Queens University Belfast (QUB)
Lecture notes of 8 pages for the course Medicine at QUB (Infection)
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MICROBIOMEMapping key components of the microbiome to
specific human body sites
Microbiome is part of the normal physiological
structure of our body so we should be aware of
its presence and where in the body it is found
There are tissues in
healthypeople that are
considered as sterile with no microorganismspresent
we are constantly interaction with patients and we
know there is the potential for microorganisms to spread
We must know how to interpret microbiological tests
telling us what bacteria are present in pt samples Central
to this is knowing what m 10 are found at body sites
Damage to the microbiome can lead to disease stales
We must know what is normal to prevent I treat
Where is the microbiome
Non sterile Sterile
G1 tract Resp Blood
Skin CSF
Mouth Tissue 1 organ
vagina parenchyma
conjunctiva
, The microbiome is at the interface between self and
non self Humans evolved in an environment already
filled with prokaryotes So we have co evolved with
bacteria and it is not surprising we contain a layer
Bacteria are
categorised here accordingto their phyla
not
gram stain genus or species onlyin microbiome
Mucous at membranes and areas covered with micro
organisms are nonsterile normal
Sterile sites should not detect if some
anyorganisms
do grow it is considered abnormal
Firmicutes
Phyla
Bacteroidetes
Actinobacteria
Proteobacteria
Principalcomponent
analysis variation
due tochanges in
temp moisture etc
Nasal phyla show
some
similarity
with skin 1 oralphyla
Skin swab growing proprionibacterium is normal
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