Lecture notes
TUMORS OF SMALL AND LARGE INTESTINES
- Module
- Institution
- Book
High yield notes of tumors of intestine with all important concepts.
[Show more]
Connected book
Book Title:
Author(s):
- Edition:
- ISBN:
- Edition:
More summaries for
-
Robbins adn cortan pathology, Neoplasia chapter 7 summery
-
ROBBINS AND COTRAN PATHOLOGIC BASIS OF DISEASE, Ninth Edition Anki flashcard
-
Necrosis
Seller
Follow
Hussain998
Content preview
TUMORS OF SMALL AND LARGE INTESTINESCOLONIC POLYPS
Raised outgrowth of COLONIC MUCOSA protruding into lumen.
May be pre-cancerous.
Removal can prevent colon cancer.
POLYPS CAN BE CLASSIFIED AS:
NON-NEOPLASTIC POLYPS:
1. INFLAMMATORY POLYPS.
2. HYPERPLASTIC POLYPS.
3. HAMARTAMATOUS POLYPS.
NEOPLASTIC POLYPS:
1. ADENOMAS/ ADENOMATOUS POLYPS.
2. ADENOCARCINOMA / COLON CANCER.
HYPERPLASTIC POLYPS
Decreased epithelial cell turnover and delayed shedding of surface epithelial cells leading to
pilling up of goblet and absorptive cells.
Usually Benign
Most common type of polyp.
Common in rectosigmoid colon/ left colon.
Normal cellular structure, no dysplasia, no malignant potential.
Less than 5mm in diameter.
Classically have a “saw tooth” or serrated pattern. Morphologic Hallmark
Usually, no special screening required after biopsy.
, INFLAMMATORY POLYPS
Occur because of chronic cycles of injury and healing.
Classic triad: rectal bleeding, mucous discharge, and inflammatory lesions on anterior rectal
wall.
E.g Solitary rectal ulcer syndrome.
Doesn’t increase the risk of malignancy.
HAMARTAMATOUS POLYPS
A hamartoma is a local malformation made up of an abnormal mixture of cells and tissue.
Caused by germline mutations in proto-oncogenes or tumor suppressor genes.
2 types:
1. Juvenile polyps
2. Peutz jeghers syndrome
1. JUVENILE POLYPS
Focal malformations of epithelium and lamina propria.
Occur in children < 5 years
Usually, pedunculated.
Solitary lesions are called retention polyps ( no malignant potential ).
JUVENILE POLYPOSIS SYNDROME:
Autosomal dominant disorder, mutations of SMAD 4 gene.
Multiple juvenile polyps ( 50-100 ).
Increased risk of cancer.
Extra intestinal manifestations: Pulmonary Arteriovenous Malformations.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Hussain998. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £2.43. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67232 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now